Fosaprepitant has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Pimozide, Alprazolam, Clarithromycin. Patients taking Fosaprepitant should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 1
- Major
- 15
- Moderate
- 4
Contraindicated (1)
- Fosaprepitant + Pimozide— Fosaprepitant is contraindicated with pimozide due to increased pimozide exposure via CYP3A4 inhibition.
Major (15)
- Fosaprepitant + Alprazolam— Increased alprazolam exposure may increase the risk of adverse reactions. Monitor for benzodiazepine-related adverse rea…
- Fosaprepitant + Clarithromycin— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Dexamethasone— Increased dexamethasone exposure. Reduce oral dexamethasone dose by approximately 50%.
- Fosaprepitant + Ifosfamide— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Fosaprepitant + Itraconazole— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Ketoconazole— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Methylprednisolone— Increased methylprednisolone exposure. Reduce oral dose by 50% on Days 1-2 (HEC) or Day 1 (MEC); reduce IV dose by 25%.
- Fosaprepitant + Midazolam— Increased midazolam exposure may increase the risk of adverse reactions. Monitor for benzodiazepine-related adverse reac…
- Fosaprepitant + Nelfinavir— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Oral Contraceptives— Decreased hormonal exposure during and for 28 days after administration. Use alternative or back-up contraception method…
- Fosaprepitant + Ritonavir— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Triazolam— Increased triazolam exposure may increase the risk of adverse reactions. Monitor for benzodiazepine-related adverse reac…
- Fosaprepitant + Troleandomycin— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Fosaprepitant + Vinblastine— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
- Fosaprepitant + Vincristine— Increased exposure of chemotherapeutic agent may increase risk of adverse reactions. Monitor for chemotherapeutic-relate…
Moderate (4)
- Fosaprepitant + Docetaxel— Increased exposure of chemotherapeutic agent; no dosage adjustment needed but monitor for adverse effects.
- Fosaprepitant + Etoposide— Increased exposure of chemotherapeutic agent; no dosage adjustment needed but monitor for adverse effects.
- Fosaprepitant + Paclitaxel— Increased exposure of chemotherapeutic agent; no dosage adjustment needed but monitor for adverse effects.
- Fosaprepitant + Vinorelbine— Increased exposure of chemotherapeutic agent; no dosage adjustment needed but monitor for adverse effects.