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Andthiazide

69 interactions on record

Andthiazide has 69 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Allopurinol, Aminolevulinic Acid Hydrochloride, Cyclophosphamide. Patients taking Andthiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 69
Major: 8
Moderate: 61

Major (8)

Andthiazide + Allopurinol— May increase risk of skin rash and hypersensitivity; renal impairment further increases risk. Monitor kidney function an…
Andthiazide + Aminolevulinic Acid Hydrochloride— Phototoxic agents that may cause severe phototoxic skin reaction (severe sunburn). Avoid for 24 hours before and after A…
Andthiazide + Cyclophosphamide— Increased hematotoxicity and immunosuppression may result from combined effect with cyclophosphamide.
Andthiazide + Ergocalciferol— Administration of thiazide diuretics to hypoparathyroid patients concurrently treated with ergocalciferol may cause hype…
Andthiazide + Ergocalciferol Capsules,— Administration of thiazide diuretics to hypoparathyroid patients concurrently treated with ergocalciferol may cause hype…
Andthiazide + Paricalcitol— Thiazide diuretics induce hypercalcemia by reducing urinary calcium excretion. Monitor calcium frequently and adjust par…
Andthiazide + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate— Avoid concomitant use due to increased risk of hypercalcemia. If unavoidable, closely monitor serum calcium concentratio…
Andthiazide + Sulfamethoxazole And Trimethoprim— In elderly patients concurrently receiving thiazide diuretics, an increased incidence of thrombocytopenia with purpura h…

Moderate (61)

Andthiazide + Albuterol— Non-potassium-sparing thiazide diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especi…
Andthiazide + Albuterol Sulfate— Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at ex…
Andthiazide + Allopurinol Sodium— May increase risk of skin rash and hypersensitivity; renal impairment further increases risk. Monitor renal function and…
Andthiazide + Alogliptin And Metformin Hydrochloride— May produce hyperglycemia and lead to loss of glycemic control.
Andthiazide + Arformoterol Tartrate— Non-potassium sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists. Use with ca…
Andthiazide + Bupivacaine And Meloxicam— Meloxicam (NSAID) can reduce the natriuretic effect of thiazide diuretics. Monitor diuretic efficacy including antihyper…
Andthiazide + Calcium Chloride— Increases risk of hypercalcemia when used concomitantly. Increase frequency of calcium concentration monitoring.
Andthiazide + Calcium Chloride Dihydrate— Increases risk of hypercalcemia. Increase frequency of calcium concentration monitoring.
Andthiazide + Calcium Gluconate— Concurrent administration may cause hypercalcemia. Monitor plasma calcium concentrations.
Andthiazide + Celecoxib— NSAIDs can reduce natriuretic effect and antihypertensive effects. Monitor diuretic efficacy.
Andthiazide + Cholestyramine Light— Cholestyramine may delay or reduce the absorption of thiazide diuretics (acidic).
Andthiazide + Cholestyramine Powder For Suspension— Cholestyramine may delay or reduce the absorption of thiazide diuretics (acidic).
Andthiazide + Choleystyramine Light— Cholestyramine may delay or reduce absorption of thiazide diuretics (acidic).
Andthiazide + Cyclophosphamide Injection, Solution— Thiazide diuretics can potentiate cyclophosphamide's hematotoxicity and immunosuppression.
Andthiazide + Desmopressin Acetate— Concomitant use may increase risk of water intoxication with hyponatremia; requires more frequent serum sodium monitorin…
Andthiazide + Desmopressin Acetate Oral Solution— May increase risk of water intoxication with hyponatremia. Monitor serum sodium more frequently.
Andthiazide + Dichlorphenamide— Increased risk of hypokalemia with coadministration of dichlorphenamide and thiazide diuretics.
Andthiazide + Diclofenac— NSAIDs can reduce natriuretic effect; monitor patients to assure diuretic efficacy including antihypertensive effects.
Andthiazide + Diclofenac Potassium— NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor patients to assure diuretic efficacy including antih…
Andthiazide + Diclofenac Sodium— NSAIDs can reduce natriuretic effect. Monitor diuretic efficacy and antihypertensive effects.
Andthiazide + Diclofenac Sodium And Misoprostol— NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor patients to assure diuretic efficacy including antih…
Andthiazide + Diclofenac Sodium Topical— NSAIDs can reduce the natriuretic effect of thiazide diuretics.
Andthiazide + Doxercalciferol— Thiazide diuretics induce hypercalcemia by reducing urinary calcium excretion, increasing risk when used with doxercalci…
Andthiazide + Fluticasone Furoate And Vilanterol— Electrocardiographic changes and hypokalemia may be worsened by vilanterol, especially at higher doses.
Andthiazide + Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at …
Andthiazide + Formoterol Fumarate Dihydrate— Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can worsen with concurrent beta-agonists. Use…
Andthiazide + Glipizide— Tend to produce hyperglycemia and may lead to loss of glipizide control. Monitor for loss of control when administered o…
Andthiazide + Glipizide And Metformin Hydrochloride— Thiazide diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation needed…
Andthiazide + Glyburide And Metformin Hydrochloride— Thiazide diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation requir…
Andthiazide + Indomethacin— In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics: NSAIDs can reduce natriuretic…
Andthiazide + Ipratropium Bromide And Albuterol Sulfate— Non-potassium sparing diuretics can worsen ECG changes and hypokalemia induced by β-agonists, especially at higher doses…
Andthiazide + Levalbuterol— May worsen ECG changes or hypokalemia. Monitor potassium levels during coadministration.
Andthiazide + Levalbuterol Hydrochloride— May worsen ECG changes or hypokalemia. Consider monitoring potassium levels during coadministration.
Andthiazide + Levalbuterol Inhalation Solution— May worsen electrocardiographic changes and hypokalemia. Monitor potassium levels during coadministration.
Andthiazide + Linagliptin And Metformin Hydrochloride— May produce hyperglycemia and lead to loss of glycemic control. Closely observe patient to maintain adequate glycemic co…
Andthiazide + Meloxicam— NSAIDs can reduce the natriuretic and antihypertensive effects of thiazide diuretics. Monitor diuretic efficacy.
Andthiazide + Meloxicam, Rizatriptan— Meloxicam can reduce natriuretic effect of thiazide diuretics. Monitor diuretic efficacy and antihypertensive effects.
Andthiazide + Metformin— Diuretic that produces hyperglycemia and may lead to loss of glycemic control when used with metformin.
Andthiazide + Metformin Er 500 Mg— May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose contro…
Andthiazide + Metformin Hydrochloride— Diuretic that may cause hyperglycemia and loss of glycemic control; monitor blood glucose closely.
Andthiazide + Metformin Hydrochloride Extended-Release Tablets— May produce hyperglycemia and lead to loss of glycemic control; monitor blood glucose closely.
Andthiazide + Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Andthiazide + Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Andthiazide + Penicillin G— Compete with penicillin G for renal tubular secretion, prolonging serum half-life.
Andthiazide + Penicillin G Potassium— Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Andthiazide + Penicillin G Sodium— Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
Andthiazide + Piroxicam— NSAIDs can reduce natriuretic effect of thiazide diuretics; monitor diuretic efficacy including antihypertensive effects…
Andthiazide + Porfimer Sodium— Concomitant use may increase the risk of photosensitivity reaction. Avoid concomitant use with other photosensitizing ag…
Andthiazide + Quinidine Gluconate— Thiazide diuretics alkalinize urine and reduce renal elimination of quinidine.
Andthiazide + Quinidine Sulfate Tablet— Alkalinize urine and reduce renal elimination of quinidine, increasing quinidine levels.
Andthiazide + Ramipril— Ramipril can attenuate potassium loss caused by thiazide diuretics. Monitor for hypokalemia.
Andthiazide + Salmeterol Xinafoate— Non-potassium-sparing diuretics may have ECG changes and hypokalemia worsened by salmeterol, especially at higher doses.
Andthiazide + Sitagliptin And Metformin Hydrochloride— May produce hyperglycemia and lead to loss of glycemic control. Monitor blood glucose closely during concomitant use.
Andthiazide + Sodium Chloride, Calcium Chloride, And Potassium Chloride— Concomitant use increases risk of hypercalcemia. Avoid use; if unavoidable, closely monitor serum calcium concentrations…
Andthiazide + Sulfadiazine— Potentiation of the action of thiazide diuretics may be noted, possibly due to displacement from albumin or pharmacodyna…
Andthiazide + Sumatriptan Succinate And Naproxen Sodium— NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor diuretic efficacy including antihypertensive effects…
Andthiazide + Terbutaline Sulfate— Nonpotassium-sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists, especially a…
Andthiazide + Toremifene Citrate— Thiazide diuretics decrease renal calcium excretion and may increase the risk of hypercalcemia in patients receiving tor…
Andthiazide + Umeclidinium Bromide And Vilanterol Trifenatate— May worsen electrocardiographic changes and/or hypokalemia associated with non-potassium-sparing diuretics when combined…
Andthiazide + Urinary Antiseptic Antispasmodic— May cause urine to become alkaline, reducing the effectiveness of methenamine by inhibiting its conversion to formaldehy…
Andthiazide + Verteporfin For Injection— Other photosensitizing agents that could increase the potential for skin photosensitivity reactions.

Andthiazide + Allopurinol⚠️Major

May increase risk of skin rash and hypersensitivity; renal impairment further increases risk. Monitor kidney function and reduce allopurinol dose.

Andthiazide + Aminolevulinic Acid Hydrochloride⚠️Major

Phototoxic agents that may cause severe phototoxic skin reaction (severe sunburn). Avoid for 24 hours before and after ALA administration.

Andthiazide + Cyclophosphamide⚠️Major

Increased hematotoxicity and immunosuppression may result from combined effect with cyclophosphamide.

Andthiazide + Ergocalciferol⚠️Major

Administration of thiazide diuretics to hypoparathyroid patients concurrently treated with ergocalciferol may cause hypercalcemia.

Andthiazide + Ergocalciferol Capsules,⚠️Major

Administration of thiazide diuretics to hypoparathyroid patients concurrently treated with ergocalciferol may cause hypercalcemia.

Andthiazide + Paricalcitol⚠️Major

Thiazide diuretics induce hypercalcemia by reducing urinary calcium excretion. Monitor calcium frequently and adjust paricalcitol dose as needed.

Andthiazide + Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride And Dextrose Monohydrate⚠️Major

Avoid concomitant use due to increased risk of hypercalcemia. If unavoidable, closely monitor serum calcium concentrations.

Andthiazide + Sulfamethoxazole And Trimethoprim⚠️Major

In elderly patients concurrently receiving thiazide diuretics, an increased incidence of thrombocytopenia with purpura has been reported.

Andthiazide + Albuterol🟡Moderate

Non-potassium-sparing thiazide diuretics can cause ECG changes and hypokalemia that may be worsened by albuterol, especially at higher doses. Caution advised in co-administration.

Andthiazide + Albuterol Sulfate🟡Moderate

Non-potassium sparing diuretics can have ECG changes and hypokalemia acutely worsened by beta-agonists, especially at exceeded doses. Caution advised in co-administration.

Andthiazide + Allopurinol Sodium🟡Moderate

May increase risk of skin rash and hypersensitivity; renal impairment further increases risk. Monitor renal function and reduce allopurinol dose.

Andthiazide + Alogliptin And Metformin Hydrochloride🟡Moderate

May produce hyperglycemia and lead to loss of glycemic control.

Andthiazide + Arformoterol Tartrate🟡Moderate

Non-potassium sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists. Use with caution.

Andthiazide + Bupivacaine And Meloxicam🟡Moderate

Meloxicam (NSAID) can reduce the natriuretic effect of thiazide diuretics. Monitor diuretic efficacy including antihypertensive effect.

Andthiazide + Calcium Chloride🟡Moderate

Increases risk of hypercalcemia when used concomitantly. Increase frequency of calcium concentration monitoring.

Andthiazide + Calcium Chloride Dihydrate🟡Moderate

Increases risk of hypercalcemia. Increase frequency of calcium concentration monitoring.

Andthiazide + Calcium Gluconate🟡Moderate

Concurrent administration may cause hypercalcemia. Monitor plasma calcium concentrations.

Andthiazide + Celecoxib🟡Moderate

NSAIDs can reduce natriuretic effect and antihypertensive effects. Monitor diuretic efficacy.

Andthiazide + Cholestyramine Light🟡Moderate

Cholestyramine may delay or reduce the absorption of thiazide diuretics (acidic).

Andthiazide + Cholestyramine Powder For Suspension🟡Moderate

Cholestyramine may delay or reduce the absorption of thiazide diuretics (acidic).

Andthiazide + Choleystyramine Light🟡Moderate

Cholestyramine may delay or reduce absorption of thiazide diuretics (acidic).

Andthiazide + Cyclophosphamide Injection, Solution🟡Moderate

Thiazide diuretics can potentiate cyclophosphamide's hematotoxicity and immunosuppression.

Andthiazide + Desmopressin Acetate🟡Moderate

Concomitant use may increase risk of water intoxication with hyponatremia; requires more frequent serum sodium monitoring.

Andthiazide + Desmopressin Acetate Oral Solution🟡Moderate

May increase risk of water intoxication with hyponatremia. Monitor serum sodium more frequently.

Andthiazide + Dichlorphenamide🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and thiazide diuretics.

Andthiazide + Diclofenac🟡Moderate

NSAIDs can reduce natriuretic effect; monitor patients to assure diuretic efficacy including antihypertensive effects.

Andthiazide + Diclofenac Potassium🟡Moderate

NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects.

Andthiazide + Diclofenac Sodium🟡Moderate

NSAIDs can reduce natriuretic effect. Monitor diuretic efficacy and antihypertensive effects.

Andthiazide + Diclofenac Sodium And Misoprostol🟡Moderate

NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor patients to assure diuretic efficacy including antihypertensive effects.

Andthiazide + Diclofenac Sodium Topical🟡Moderate

NSAIDs can reduce the natriuretic effect of thiazide diuretics.

Andthiazide + Doxercalciferol🟡Moderate

Thiazide diuretics induce hypercalcemia by reducing urinary calcium excretion, increasing risk when used with doxercalciferol. Monitor serum calcium concentrations.

Andthiazide + Fluticasone Furoate And Vilanterol🟡Moderate

Electrocardiographic changes and hypokalemia may be worsened by vilanterol, especially at higher doses.

Andthiazide + Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can be worsened by vilanterol, especially at higher doses.

Andthiazide + Formoterol Fumarate Dihydrate🟡Moderate

Non-potassium-sparing diuretics may cause hypokalemia and ECG changes that can worsen with concurrent beta-agonists. Use with caution.

Andthiazide + Glipizide🟡Moderate

Tend to produce hyperglycemia and may lead to loss of glipizide control. Monitor for loss of control when administered or withdrawn.

Andthiazide + Glipizide And Metformin Hydrochloride🟡Moderate

Thiazide diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation needed for loss of blood glucose control.

Andthiazide + Glyburide And Metformin Hydrochloride🟡Moderate

Thiazide diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Andthiazide + Indomethacin🟡Moderate

In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics: NSAIDs can reduce natriuretic effect of furosemide andthiazide diuretics.

Andthiazide + Ipratropium Bromide And Albuterol Sulfate🟡Moderate

Non-potassium sparing diuretics can worsen ECG changes and hypokalemia induced by β-agonists, especially at higher doses.

Andthiazide + Levalbuterol🟡Moderate

May worsen ECG changes or hypokalemia. Monitor potassium levels during coadministration.

Andthiazide + Levalbuterol Hydrochloride🟡Moderate

May worsen ECG changes or hypokalemia. Consider monitoring potassium levels during coadministration.

Andthiazide + Levalbuterol Inhalation Solution🟡Moderate

May worsen electrocardiographic changes and hypokalemia. Monitor potassium levels during coadministration.

Andthiazide + Linagliptin And Metformin Hydrochloride🟡Moderate

May produce hyperglycemia and lead to loss of glycemic control. Closely observe patient to maintain adequate glycemic control.

Andthiazide + Meloxicam🟡Moderate

NSAIDs can reduce the natriuretic and antihypertensive effects of thiazide diuretics. Monitor diuretic efficacy.

Andthiazide + Meloxicam, Rizatriptan🟡Moderate

Meloxicam can reduce natriuretic effect of thiazide diuretics. Monitor diuretic efficacy and antihypertensive effects.

Andthiazide + Metformin🟡Moderate

Diuretic that produces hyperglycemia and may lead to loss of glycemic control when used with metformin.

Andthiazide + Metformin Er 500 Mg🟡Moderate

May produce hyperglycemia and lead to loss of glycemic control. Monitor patient closely for loss of blood glucose control.

Andthiazide + Metformin Hydrochloride🟡Moderate

Diuretic that may cause hyperglycemia and loss of glycemic control; monitor blood glucose closely.

Andthiazide + Metformin Hydrochloride Extended-Release Tablets🟡Moderate

May produce hyperglycemia and lead to loss of glycemic control; monitor blood glucose closely.

Andthiazide + Methenamine, Sodium Phosphate, Monobasic, Methylene Blue, And Hyoscyamine Sulfate🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Andthiazide + Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Andthiazide + Penicillin G🟡Moderate

Compete with penicillin G for renal tubular secretion, prolonging serum half-life.

Andthiazide + Penicillin G Potassium🟡Moderate

Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Andthiazide + Penicillin G Sodium🟡Moderate

Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.

Andthiazide + Piroxicam🟡Moderate

NSAIDs can reduce natriuretic effect of thiazide diuretics; monitor diuretic efficacy including antihypertensive effects.

Andthiazide + Porfimer Sodium🟡Moderate

Concomitant use may increase the risk of photosensitivity reaction. Avoid concomitant use with other photosensitizing agents.

Andthiazide + Quinidine Gluconate🟡Moderate

Thiazide diuretics alkalinize urine and reduce renal elimination of quinidine.

Andthiazide + Quinidine Sulfate Tablet🟡Moderate

Alkalinize urine and reduce renal elimination of quinidine, increasing quinidine levels.

Andthiazide + Ramipril🟡Moderate

Ramipril can attenuate potassium loss caused by thiazide diuretics. Monitor for hypokalemia.

Andthiazide + Salmeterol Xinafoate🟡Moderate

Non-potassium-sparing diuretics may have ECG changes and hypokalemia worsened by salmeterol, especially at higher doses.

Andthiazide + Sitagliptin And Metformin Hydrochloride🟡Moderate

May produce hyperglycemia and lead to loss of glycemic control. Monitor blood glucose closely during concomitant use.

Andthiazide + Sodium Chloride, Calcium Chloride, And Potassium Chloride🟡Moderate

Concomitant use increases risk of hypercalcemia. Avoid use; if unavoidable, closely monitor serum calcium concentrations.

Andthiazide + Sulfadiazine🟡Moderate

Potentiation of the action of thiazide diuretics may be noted, possibly due to displacement from albumin or pharmacodynamic mechanism.

Andthiazide + Sumatriptan Succinate And Naproxen Sodium🟡Moderate

NSAIDs can reduce natriuretic effect of thiazide diuretics. Monitor diuretic efficacy including antihypertensive effects.

Andthiazide + Terbutaline Sulfate🟡Moderate

Nonpotassium-sparing diuretics may cause ECG changes and hypokalemia that can be worsened by beta-agonists, especially at higher doses.

Andthiazide + Toremifene Citrate🟡Moderate

Thiazide diuretics decrease renal calcium excretion and may increase the risk of hypercalcemia in patients receiving toremifene citrate.

Andthiazide + Umeclidinium Bromide And Vilanterol Trifenatate🟡Moderate

May worsen electrocardiographic changes and/or hypokalemia associated with non-potassium-sparing diuretics when combined with beta-agonists. Use with caution.

Andthiazide + Urinary Antiseptic Antispasmodic🟡Moderate

May cause urine to become alkaline, reducing the effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Andthiazide + Verteporfin For Injection🟡Moderate

Other photosensitizing agents that could increase the potential for skin photosensitivity reactions.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.