Butorpenol has 11 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv, Atropa Belladonna And Opium. Patients taking Butorpenol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 8
- Moderate
- 3
Major (8)
- Butorpenol + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
- Butorpenol + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…
- Butorpenol + Atropa Belladonna And Opium— Mixed agonist/antagonist opioid may reduce analgesic effect and/or precipitate withdrawal symptoms. Avoid concomitant us…
- Butorpenol + Hydrocodone Bitartrate And Acetaminophen— Mixed agonist/antagonist analgesic may precipitate withdrawal in opioid-dependent patients.
- Butorpenol + Hydromorphone Hydrochloride— May reduce analgesic effect of hydromorphone and/or precipitate withdrawal symptoms. Avoid concomitant use.
- Butorpenol + Levorphanol Tartrate— Mixed agonist/antagonist opioid may reduce analgesic effect of levorphanol and precipitate withdrawal symptoms. Advise p…
- Butorpenol + Morphine Sulfate— Mixed agonist/antagonist opioid may reduce analgesic effect of morphine and/or precipitate withdrawal symptoms; avoid co…
- Butorpenol + Pentazocine Hydrochloride And Naloxone Hydrochloride— Mixed agonist/antagonist opioid may reduce analgesic effect and precipitate withdrawal symptoms. Avoid concomitant use.
Moderate (3)
- Butorpenol + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Mixed agonist/antagonist opioid may reduce the analgesic effect of this combination product.
- Butorpenol + Oxycodone Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect and/or precipitate withdrawal symptoms in opioid-dependent patients…
- Butorpenol + Remifentanil Hydrochloride— Mixed agonist/antagonist may reduce analgesic effect of remifentanil and/or precipitate withdrawal symptoms.