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Calcifediol

Also known as: Rayaldee

Route: Oral

Check Calcifediol Interactions →

14 interactions on record

Calcifediol has 14 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Atazanavir, Cholestyramine Light, Clarithromycin. Patients taking Calcifediol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 14
Moderate: 14

Moderate (14)

Calcifediol + Atazanavir— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Cholestyramine Light— May impair absorption of calcifediol. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may …
Calcifediol + Clarithromycin— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Indinavir— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Itraconazole— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Ketoconazole— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Nefazodone— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Nelfinavir— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Phenobarbital— Stimulates microsomal hydroxylation and reduces the half-life of calcifediol. Dose adjustment and monitoring of serum 25…
Calcifediol + Ritonavir— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Saquinavir— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Telithromycin— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…
Calcifediol + Thiazides— Concomitant administration may cause hypercalcemia due to thiazide-induced reduction in urinary calcium excretion. More …
Calcifediol + Voriconazole— CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and m…

Calcifediol + Atazanavir🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Cholestyramine Light🟡Moderate

May impair absorption of calcifediol. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Clarithromycin🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Indinavir🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Itraconazole🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Ketoconazole🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Nefazodone🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Nelfinavir🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Phenobarbital🟡Moderate

Stimulates microsomal hydroxylation and reduces the half-life of calcifediol. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Ritonavir🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Saquinavir🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Telithromycin🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Calcifediol + Thiazides🟡Moderate

Concomitant administration may cause hypercalcemia due to thiazide-induced reduction in urinary calcium excretion. More frequent serum calcium monitoring required.

Calcifediol + Voriconazole🟡Moderate

CYP3A4 inhibitor may alter serum levels of calcifediol by inhibiting vitamin D metabolism enzymes. Dose adjustment and monitoring of serum 25-hydroxyvitamin D, PTH, and calcium may be required.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.