Calcitriol has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Vitamin D, Antacids Containing Magnesium, Digitalis Glycosides. Patients taking Calcitriol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 1
- Major
- 3
- Moderate
- 9
Contraindicated (1)
- Calcitriol + Vitamin D— Pharmacological doses of vitamin D and derivatives should be withheld during calcitriol treatment to avoid additive effe…
Major (3)
- Calcitriol + Antacids Containing Magnesium— Magnesium-containing preparations may cause hypermagnesemia and should not be taken during calcitriol therapy in chronic…
- Calcitriol + Digitalis Glycosides— Hypercalcemia may precipitate cardiac arrhythmias in patients on digitalis therapy; careful dosage determination require…
- Calcitriol + Thiazides— Concomitant administration of thiazides with calcitriol causes hypercalcemia due to reduction of calcium excretion in ur…
Moderate (9)
- Calcitriol + Calcium Antagonists— Uncontrolled intake of additional calcium-containing preparations should be avoided.
- Calcitriol + Carbamazepine— May reduce the effects of calcitriol by increasing vitamin D catabolism.
- Calcitriol + Cholestyramine Light— May impair intestinal absorption of calcitriol by reducing absorption of fat-soluble vitamins.
- Calcitriol + Corticosteroids— Functional antagonism exists; corticosteroids inhibit calcium absorption while calcitriol promotes it.
- Calcitriol + Iron-Containing Preparations— Concomitant use may lead to development of hypermagnesemia. Should be used with caution or avoided.
- Calcitriol + Ketoconazole— May inhibit synthetic and catabolic enzymes of calcitriol, reducing serum endogenous calcitriol concentrations.
- Calcitriol + Phenobarbital— May reduce endogenous plasma levels of 25(OH)D3 by accelerating metabolism, potentially requiring higher calcitriol dose…
- Calcitriol + Phenytoin— May reduce endogenous plasma levels of 25(OH)D3 by accelerating metabolism, potentially requiring higher calcitriol dose…
- Calcitriol + Phosphate-Binding Agents— Dosage adjustment required as calcitriol affects phosphate transport; dosing must be adjusted based on serum phosphate l…