Calcium Chloride Interactions

Brand names: Calcium Chloride

Route: Intravenous

Contraindications

4 CONTRAINDICATIONS Calcium chloride injection is contraindicated in: Patients with ventricular fibrillation Patients with asystole and electromechanical dissociation Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at different times or through separate intravenous lines [see Warnings and Precautions (5.1) ] . Calcium chloride injection is contraindicated in: Patients with ventricular fibrillation. ( 4 ) Patients with asystole and electromechanical dissociation. ( 4 ) Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment, regardless of whether these products would be received at different times or through separate intravenous lines. ( 4 , 5.1 )

Pregnancy & Breastfeeding

8.1 Pregnancy Risk Summary Administration of Calcium Chloride Injection for the treatment of acute symptomatic hypocalcemia during pregnancy is not expected to cause major birth defects, miscarriage, or adverse maternal or fetal outcomes. There are risks to the mother and the fetus associated with development of hypocalcemia during pregnancy (see Clinical Considerations). Animal reproduction studies have not been conducted with Calcium Chloride Injection. The estimated background risk of major birth defects and miscarriage for the indicated populations are unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Clinical Considerations Disease-associated Maternal and/or Embryo/Fetal/Neonatal Risk Maternal hypocalcemia can result in an increased rate of spontaneous abortion, premature and dysfunctional labor, and possibly preeclampsia. Infants born to mothers with hypocalcemia can develop fetal and neonatal hyperparathyroidism, which in turn can cause fetal and neonatal skeletal demineralization, subperiosteal bone resorption, osteitis fibrosa cystica and neonatal seizures.

11 interactions on record

Calcium Chloride + Digitalis GlycosidesContraindicated

Danger with simultaneous use of calcium salts and digitalis drugs. A digitalized patient should not receive IV calcium unless indications are clearly defined.

Source: NLP:calcium chloride

Calcium Chloride + Calcium Channel BlockersMajor

Avoid concomitant use; calcium chloride may reduce response to calcium channel blockers. Monitor blood pressure closely if use unavoidable.

Source: NLP:calcium chloride

Calcium Chloride + DigoxinMajor

Avoid concomitant use; synergistic arrhythmias may occur. Calcium chloride may cause hypercalcemia, increasing risk of digoxin toxicity. Monitor ECG closely if use unavoidable.

Source: NLP:calcium chloride

Calcium Chloride + AndthiazideModerate