Rydapt has 29 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Enzalutamide, Mitotane. Patients taking Rydapt should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 29
- Major
- 6
- Moderate
- 23
Major (6)
- Rydapt + Carbamazepine— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
- Rydapt + Enzalutamide— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
- Rydapt + Mitotane— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
- Rydapt + Phenytoin— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
- Rydapt + Rifampin— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration.
- Rydapt + St. John'S Wort— Strong CYP3A4 inducer that decreases midostaurin concentrations and may reduce efficacy. Avoid coadministration. Inducti…
Moderate (23)
- Rydapt + Boceprevir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Clarithromycin— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Cobicistat— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Conivaptan— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Dasabuvir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Diltiazem— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Elvitegravir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Grapefruit Juice— Strong CYP3A4 inhibitor (with certain preparations) that may increase midostaurin concentrations. Effect varies by brand…
- Rydapt + Idelalisib— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Indinavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Itraconazole— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Ketoconazole— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Lopinavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Nefazodone— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Nelfinavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Ombitasvir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Paritaprevir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Posaconazole— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Ritonavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Saquinavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Tipranavir— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Troleandomycin— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…
- Rydapt + Voriconazole— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…