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Abemaciclib

Also known as: Verzenio

Kinase InhibitorKinase Inhibitors

Route: Oral

6 interactions on record

Abemaciclib has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ketoconazole, Lopinavir And Ritonavir, Ritonavir. Patients taking Abemaciclib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Contraindicated: 4
Major: 2

Contraindicated (4)

Abemaciclib + Ketoconazole— Ketoconazole is predicted to increase abemaciclib AUC up to 16-fold, leading to increased toxicity. Concomitant use shou…
Abemaciclib + Lopinavir And Ritonavir— Anticancer Agents: abemaciclib, apalutamide, encorafenib, ibrutinib, ivosidenib, dasatinib, neratinib, nilotinib, veneto…
Abemaciclib + Ritonavir— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…
Abemaciclib + Ritonavir 100 Mg— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…

Major (2)

Abemaciclib + Grapefruit Products— Grapefruit products should be avoided due to CYP3A4 inhibition, which increases abemaciclib exposure and toxicity risk.
Abemaciclib + Nirmatrelvir And Ritonavir— Anticancer drugs abemaciclib, ceritinib, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax…

Abemaciclib + Ketoconazole⛔Contraindicated

Ketoconazole is predicted to increase abemaciclib AUC up to 16-fold, leading to increased toxicity. Concomitant use should be avoided.

Abemaciclib + Lopinavir And Ritonavir⛔Contraindicated

Anticancer Agents: abemaciclib, apalutamide, encorafenib, ibrutinib, ivosidenib, dasatinib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer agents ↓lopinavir/ritonavir # Apalutamide is contraindicated due to potential for loss of virologic response and possible resistance to KALETRA or to the class of protease inhibitors [see Contraindications ( 4 )] .

Abemaciclib + Ritonavir⛔Contraindicated

Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer agents ↓ ritonavir # Apalutamide is contraindicated due to potential for loss of virologic response and possible resistance to NORVIR or to the class of protease inhibitors [see Contraindications ( 4 ) ] .

Abemaciclib + Ritonavir 100 Mg⛔Contraindicated

Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer agents ↓ ritonavir # Apalutamide is contraindicated due to potential for loss of virologic response and possible resistance to ritonavir or to the class of protease inhibitors [see Contraindications ( 4 )].

Abemaciclib + Grapefruit Products⚠️Major

Grapefruit products should be avoided due to CYP3A4 inhibition, which increases abemaciclib exposure and toxicity risk.

Abemaciclib + Nirmatrelvir And Ritonavir⚠️Major

Anticancer drugs abemaciclib, ceritinib, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer drugs Avoid co-administration of encorafenib or ivosidenib due to potential risk of serious adverse events such as QT interval prolongation.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.