Abemaciclib has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ketoconazole, Lopinavir And Ritonavir, Ritonavir. Patients taking Abemaciclib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 4
- Major
- 2
Contraindicated (4)
- Abemaciclib + Ketoconazole— Ketoconazole is predicted to increase abemaciclib AUC up to 16-fold, leading to increased toxicity. Concomitant use shou…
- Abemaciclib + Lopinavir And Ritonavir— Anticancer Agents: abemaciclib, apalutamide, encorafenib, ibrutinib, ivosidenib, dasatinib, neratinib, nilotinib, veneto…
- Abemaciclib + Ritonavir— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…
- Abemaciclib + Ritonavir 100 Mg— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…
Major (2)
- Abemaciclib + Grapefruit Products— Grapefruit products should be avoided due to CYP3A4 inhibition, which increases abemaciclib exposure and toxicity risk.
- Abemaciclib + Nirmatrelvir And Ritonavir— Anticancer drugs abemaciclib, ceritinib, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax…