Budesonide has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Cyclosporine, Erythromycin, Grapefruit Juice. Patients taking Budesonide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 8
- Moderate
- 6
Contraindicated (8)
- Budesonide + Cyclosporine— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
- Budesonide + Erythromycin— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
- Budesonide + Grapefruit Juice— Inhibits CYP3A4 activity, increasing systemic budesonide exposure. Avoid ingestion with budesonide.
- Budesonide + Indinavir— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
- Budesonide + Itraconazole— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
- Budesonide + Ketoconazole— Strong CYP3A4 inhibitor causing eight-fold increase in systemic budesonide exposure. Avoid use.
- Budesonide + Ritonavir— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
- Budesonide + Saquinavir— CYP3A4 inhibitor that can increase systemic budesonide concentrations. Avoid use.
Moderate (6)
- Budesonide + Atazanavir— Caution should be exercised when considering the co-administration of PULMICORT FLEXHALER with long-term ketoconazole an…
- Budesonide + Clarithromycin— Caution should be exercised when considering the co-administration of PULMICORT FLEXHALER with long-term ketoconazole an…
- Budesonide + Deferasirox— Deferasirox may induce CYP3A4 resulting in decreased budesonide concentration. Monitor for reduced effectiveness.
- Budesonide + Nefazodone— Strong CYP3A4 inhibitor that may increase systemic exposure to budesonide. Use with caution.
- Budesonide + Nelfinavir— Caution should be exercised when considering the co-administration of PULMICORT FLEXHALER with long-term ketoconazole an…
- Budesonide + Telithromycin— Caution should be exercised when considering the co-administration of PULMICORT FLEXHALER with long-term ketoconazole an…