Caffeine Citrate has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Theophylline, Cimetidine, Ketoconazole. Patients taking Caffeine Citrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 1
- Moderate
- 5
Contraindicated (1)
- Caffeine Citrate + Theophylline— Interconversion between caffeine and theophylline has been reported in preterm neonates. Concurrent use is not recommend…
Moderate (5)
- Caffeine Citrate + Cimetidine— Decreases caffeine elimination; lower caffeine doses may be needed when coadministered.
- Caffeine Citrate + Ketoconazole— Decreases caffeine elimination; lower caffeine doses may be needed when coadministered.
- Caffeine Citrate + Ketoprofen— Concurrent use reduced urine volume in healthy volunteers; clinical significance in preterm neonates unknown.
- Caffeine Citrate + Phenobarbital— Increases caffeine elimination; higher caffeine doses may be needed when coadministered.
- Caffeine Citrate + Phenytoin— Increases caffeine elimination; higher caffeine doses may be needed when coadministered.