Pentobarbital Sodium has 17 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Antihistamines, Tranquilizers. Patients taking Pentobarbital Sodium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 3
- Moderate
- 14
Major (3)
- Pentobarbital Sodium + Alcohol— Concomitant use may produce additive CNS depressant effects.
- Pentobarbital Sodium + Antihistamines— Concomitant use may produce additive CNS depressant effects.
- Pentobarbital Sodium + Tranquilizers— Concomitant use may produce additive CNS depressant effects.
Moderate (14)
- Pentobarbital Sodium + Acenocoumarol— Barbiturates induce hepatic microsomal enzymes, increasing metabolism and decreasing anticoagulant response. Dosage adju…
- Pentobarbital Sodium + Corticosteroids— Barbiturates enhance metabolism of exogenous corticosteroids. Dosage adjustments may be needed when barbiturates are add…
- Pentobarbital Sodium + Dicumarol— Barbiturates lower plasma levels and decrease anticoagulant activity. Dosage adjustments may be needed when barbiturates…
- Pentobarbital Sodium + Doxycycline— Barbiturates shorten doxycycline half-life for up to 2 weeks after discontinuation. Clinical response should be monitore…
- Pentobarbital Sodium + Estradiol— Pretreatment with or concurrent barbiturate administration may decrease estradiol effects.
- Pentobarbital Sodium + Estrone— Pretreatment with or concurrent barbiturate administration may decrease estrone effects.
- Pentobarbital Sodium + Griseofulvin— Barbiturates interfere with absorption of orally administered griseofulvin, decreasing blood levels. Concomitant adminis…
- Pentobarbital Sodium + Monoamine Oxidase Inhibitors (Maois)— MAOIs prolong barbiturate effects by inhibiting barbiturate metabolism.
- Pentobarbital Sodium + Phenprocoumon— Barbiturates induce hepatic microsomal enzymes, increasing metabolism and decreasing anticoagulant response. Dosage adju…
- Pentobarbital Sodium + Phenytoin— Barbiturates have variable effects on phenytoin metabolism. Blood levels of both drugs should be monitored more frequent…
- Pentobarbital Sodium + Progesterone— Pretreatment with or concurrent barbiturate administration may decrease progesterone effects.
- Pentobarbital Sodium + Valproate Sodium— Sodium valproate decreases barbiturate metabolism. Barbiturate blood levels should be monitored and dosage adjustments m…
- Pentobarbital Sodium + Valproic Acid— Valproic acid decreases barbiturate metabolism. Barbiturate blood levels should be monitored and dosage adjustments made…
- Pentobarbital Sodium + Warfarin— Barbiturates induce hepatic microsomal enzymes, increasing metabolism and decreasing anticoagulant response. Dosage adju…