Penicillin G Potassium has 14 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Triamterene, Triamterene And Hydrochlorothiazide, Acetazolamide. Patients taking Penicillin G Potassium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 2
- Moderate
- 11
Major (2)
- Penicillin G Potassium + Triamterene— May promote serum potassium accumulation and result in hyperkalemia due to potassium-sparing nature of triamterene, espe…
- Penicillin G Potassium + Triamterene And Hydrochlorothiazide— Potassium-containing medications may promote serum potassium accumulation and result in hyperkalemia, especially in pati…
Moderate (11)
- Penicillin G Potassium + Acetazolamide— Bacteriostatic antibiotic may antagonize bactericidal effect of penicillin; also competes for renal tubular secretion an…
- Penicillin G Potassium + Andthiazide— Compete with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Aspirin— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Chloramphenicol— Bacteriostatic antibiotic may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Penicillin G Potassium + Erythromycin— Bacteriostatic antibiotic may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Penicillin G Potassium + Ethacrynic Acid— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Furosemide— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Indomethacin— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Phenylbutazone— Competes with penicillin G for renal tubular secretion, prolonging serum half-life of penicillin.
- Penicillin G Potassium + Probenecid— Blocks renal tubular secretion of penicillin, prolonging penicillin blood levels and serum half-life.
- Penicillin G Potassium + Tetracycline— Bacteriostatic antibiotic may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.