Propafenone Hydrochloride has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Erythromycin, Grapefruit Juice. Patients taking Propafenone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 7
- Major
- 8
- Moderate
- 2
Contraindicated (7)
- Propafenone Hydrochloride + Amiodarone— Concomitant administration can affect conduction and repolarization and is not recommended.
- Propafenone Hydrochloride + Erythromycin— CYP3A4 inhibitor; simultaneous use with both CYP2D6 and CYP3A4 inhibitors should be avoided due to increased risk of pro…
- Propafenone Hydrochloride + Grapefruit Juice— CYP3A4 inhibitor; simultaneous use with both CYP2D6 and CYP3A4 inhibitors should be avoided due to increased risk of pro…
- Propafenone Hydrochloride + Ketoconazole— CYP3A4 inhibitor; simultaneous use with both CYP2D6 and CYP3A4 inhibitors should be avoided due to increased risk of pro…
- Propafenone Hydrochloride + Quinidine— Completely inhibits CYP2D6 hydroxylation, increasing propafenone concentrations more than 2-fold; concomitant use should…
- Propafenone Hydrochloride + Ritonavir— CYP2D6 and CYP3A4 inhibitor; simultaneous use with both CYP2D6 and CYP3A4 inhibitors should be avoided due to increased …
- Propafenone Hydrochloride + Saquinavir— CYP3A4 inhibitor; simultaneous use with both CYP2D6 and CYP3A4 inhibitors should be avoided due to increased risk of pro…
Major (8)
- Propafenone Hydrochloride + Desipramine— CYP2D6 inhibitor that increases propafenone plasma levels, potentially leading to cardiac arrhythmias and proarrhythmia …
- Propafenone Hydrochloride + Digoxin— Propafenone may increase digoxin levels, requiring monitoring.
- Propafenone Hydrochloride + Fluoxetine— Increases S-propafenone and R-propafenone exposure by 39-71%, potentially increasing adverse reactions.
- Propafenone Hydrochloride + Orlistat— May reduce propafenone concentrations; abrupt cessation has resulted in convulsions, atrioventricular block, and circula…
- Propafenone Hydrochloride + Paroxetine— CYP2D6 inhibitor that increases propafenone plasma levels, potentially leading to cardiac arrhythmias and proarrhythmia …
- Propafenone Hydrochloride + Rifampin— CYP3A4 inducer that decreases propafenone plasma concentrations by 50-84%, reducing efficacy.
- Propafenone Hydrochloride + Sertraline— CYP2D6 inhibitor that increases propafenone plasma levels, potentially leading to cardiac arrhythmias and proarrhythmia …
- Propafenone Hydrochloride + Warfarin— Propafenone may increase warfarin levels, requiring monitoring.
Moderate (2)
- Propafenone Hydrochloride + Cimetidine— Increases steady-state plasma concentrations of propafenone by approximately 20%.
- Propafenone Hydrochloride + Lidocaine— Concomitant use may increase central nervous system side effects.