Home›Selegiline Hydrochloride

Selegiline Hydrochloride

Also known as: Zelapar, Anipryl

Route: Oral

Check Selegiline Hydrochloride Interactions →

10 interactions on record

Selegiline Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dextromethorphan, Linezolid, Meperidine. Patients taking Selegiline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 5
Major: 2
Moderate: 2

Contraindicated (5)

Selegiline Hydrochloride + Dextromethorphan— Combination with MAO inhibitors reported to cause brief episodes of psychosis or bizarre behavior.
Selegiline Hydrochloride + Linezolid— Contraindicated due to increased risk for hypertensive crisis; linezolid has reversible nonselective MAO inhibition acti…
Selegiline Hydrochloride + Meperidine— Combination causes stupor, muscular rigidity, severe agitation, elevated temperature, severe agitation, hallucinations, …
Selegiline Hydrochloride + Methadone— Serious, sometimes fatal reactions reported with concomitant use of methadone and MAOIs including selective MAO-B inhibi…
Selegiline Hydrochloride + Tramadol— Serious, sometimes fatal reactions reported with concomitant use of tramadol and MAOIs including selective MAO-B inhibit…

Major (2)

Selegiline Hydrochloride + Ephedrine— One case of hypertensive crisis reported in patient taking recommended doses of selegiline and ephedrine.
Selegiline Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)— Severe toxicity reported in patients receiving combination of selective serotonin reuptake inhibitors and selegiline hyd…

Moderate (2)

Selegiline Hydrochloride + Carbidopa And Levodopa— Selective MAO-B inhibitor may be used concomitantly with carbidopa/levodopa, but concomitant therapy may be associated w…
Selegiline Hydrochloride + Nafcillin— Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with ca…

Selegiline Hydrochloride + Dextromethorphan⛔Contraindicated

Combination with MAO inhibitors reported to cause brief episodes of psychosis or bizarre behavior.

Selegiline Hydrochloride + Linezolid⛔Contraindicated

Contraindicated due to increased risk for hypertensive crisis; linezolid has reversible nonselective MAO inhibition activity.

Selegiline Hydrochloride + Meperidine⛔Contraindicated

Combination causes stupor, muscular rigidity, severe agitation, elevated temperature, severe agitation, hallucinations, and death. Typical MAOI-meperidine interaction.

Selegiline Hydrochloride + Methadone⛔Contraindicated

Serious, sometimes fatal reactions reported with concomitant use of methadone and MAOIs including selective MAO-B inhibitors.

Selegiline Hydrochloride + Tramadol⛔Contraindicated

Serious, sometimes fatal reactions reported with concomitant use of tramadol and MAOIs including selective MAO-B inhibitors.

Selegiline Hydrochloride + Ephedrine⚠️Major

One case of hypertensive crisis reported in patient taking recommended doses of selegiline and ephedrine.

Selegiline Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)⚠️Major

Severe toxicity reported in patients receiving combination of selective serotonin reuptake inhibitors and selegiline hydrochloride.

Selegiline Hydrochloride + Carbidopa And Levodopa🟡Moderate

Selective MAO-B inhibitor may be used concomitantly with carbidopa/levodopa, but concomitant therapy may be associated with severe orthostatic hypotension.

Selegiline Hydrochloride + Nafcillin🟡Moderate

Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with caution.

Selegiline Hydrochloride + Metoclopramideℹ️Unknown

7.8 Dopaminergic Antagonists It is possible that dopamine antagonists, such as antipsychotics or metoclopramide, could diminish the effectiveness of ZELAPAR.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.