Selegiline Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 5 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dextromethorphan, Linezolid, Meperidine. Patients taking Selegiline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 5
- Major
- 2
- Moderate
- 2
Contraindicated (5)
- Selegiline Hydrochloride + Dextromethorphan— Combination with MAO inhibitors reported to cause brief episodes of psychosis or bizarre behavior.
- Selegiline Hydrochloride + Linezolid— Contraindicated due to increased risk for hypertensive crisis; linezolid has reversible nonselective MAO inhibition acti…
- Selegiline Hydrochloride + Meperidine— Combination causes stupor, muscular rigidity, severe agitation, elevated temperature, severe agitation, hallucinations, …
- Selegiline Hydrochloride + Methadone— Serious, sometimes fatal reactions reported with concomitant use of methadone and MAOIs including selective MAO-B inhibi…
- Selegiline Hydrochloride + Tramadol— Serious, sometimes fatal reactions reported with concomitant use of tramadol and MAOIs including selective MAO-B inhibit…
Major (2)
- Selegiline Hydrochloride + Ephedrine— One case of hypertensive crisis reported in patient taking recommended doses of selegiline and ephedrine.
- Selegiline Hydrochloride + Selective Serotonin Reuptake Inhibitors (Ssri)— Severe toxicity reported in patients receiving combination of selective serotonin reuptake inhibitors and selegiline hyd…
Moderate (2)
- Selegiline Hydrochloride + Carbidopa And Levodopa— Selective MAO-B inhibitor may be used concomitantly with carbidopa/levodopa, but concomitant therapy may be associated w…
- Selegiline Hydrochloride + Nafcillin— Drugs that induce CYP3A4 (e.g., phenytoin, carbamazepine, nafcillin, phenobarbital, and rifampin) should be used with ca…