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Fluvoxamine Maleate

Also known as: Fluvoxamine Maleate

Route: Oral

Check Fluvoxamine Maleate Interactions →

16 interactions on record⛔ Black Box Warning

Fluvoxamine Maleate has 16 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Sumatriptan, Tacrine. Patients taking Fluvoxamine Maleate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 16
Major: 4
Moderate: 8

Major (4)

Fluvoxamine Maleate + Carbamazepine— Elevated carbamazepine levels and symptoms of toxicity with co-administration.
Fluvoxamine Maleate + Sumatriptan— Rare postmarketing reports of weakness, hyperreflexia, and incoordination following use with SSRI.
Fluvoxamine Maleate + Tacrine— Coadministration increased tacrine Cmax and AUC five- and eight-fold, causing nausea, vomiting, sweating, and diarrhea.
Fluvoxamine Maleate + Tryptophan— Severe vomiting with coadministration.

Moderate (8)

Fluvoxamine Maleate + Alprazolam— Potential interaction due to fluvoxamine inhibition of CYP3A4, which is involved in alprazolam metabolism.
Fluvoxamine Maleate + Diltiazem— Bradycardia with coadministration.
Fluvoxamine Maleate + Metoprolol— Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . One case…
Fluvoxamine Maleate + Omeprazole— Potential interaction due to fluvoxamine inhibition of CYP2C19, which is involved in omeprazole metabolism.
Fluvoxamine Maleate + Propranolol— Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . Based on…
Fluvoxamine Maleate + Theophylline— Potential interaction due to fluvoxamine inhibition of CYP1A2, which is involved in theophylline metabolism.
Fluvoxamine Maleate + Tizanidine— Potential interaction due to fluvoxamine inhibition of CYP1A2, which is involved in tizanidine metabolism.
Fluvoxamine Maleate + Warfarin— Potential interaction due to fluvoxamine inhibition of CYP1A2 and CYP2C9, which are involved in warfarin metabolism.

Fluvoxamine Maleate + Carbamazepine⚠️Major

Elevated carbamazepine levels and symptoms of toxicity with co-administration.

Fluvoxamine Maleate + Sumatriptan⚠️Major

Rare postmarketing reports of weakness, hyperreflexia, and incoordination following use with SSRI.

Fluvoxamine Maleate + Tacrine⚠️Major

Coadministration increased tacrine Cmax and AUC five- and eight-fold, causing nausea, vomiting, sweating, and diarrhea.

Fluvoxamine Maleate + Tryptophan⚠️Major

Severe vomiting with coadministration.

Fluvoxamine Maleate + Alprazolam🟡Moderate

Potential interaction due to fluvoxamine inhibition of CYP3A4, which is involved in alprazolam metabolism.

Fluvoxamine Maleate + Diltiazem🟡Moderate

Bradycardia with coadministration.

Fluvoxamine Maleate + Metoprolol🟡Moderate

Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . One case of bradycardia and hypotension and a second case of orthostatic hypotension have been reported with the coadministration of immediate-release fluvoxamine maleate tablets and metoprolol. If propranolol or metoprolol is coadministered with fluvoxamine maleate extended-release capsules, a reduction in the initial beta-blocker dose and more cautious dose titration are recommended.

Fluvoxamine Maleate + Omeprazole🟡Moderate

Potential interaction due to fluvoxamine inhibition of CYP2C19, which is involved in omeprazole metabolism.

Fluvoxamine Maleate + Propranolol🟡Moderate

Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . Based on a finding of substantial interactions of fluvoxamine with certain of these drugs (see later parts of this section and also WARNINGS AND PRECAUTIONS [ 5 ] for details) and limited in vitro data for CYP3A4, it appears that fluvoxamine inhibits several cytochrome P450 isoenzymes that are known to be involved in the metabolism of other drugs such as: CYP1A2 (e.g., warfarin, theophylline, propranolol, tizanidine), CYP2C9 (e.g., warfarin), CYP3A4 (e.g., alprazolam), and CYP2C19 (e.g., omeprazole). Propranolol and Other Beta-Blockers: Coadministration of immediate-release fluvoxamine maleate tablets 100 mg per day and propranolol 160 mg per day in normal volunteers resulted in a mean five-fold increase (range 2 to 17) in minimum propranolol plasma concentrations.

Fluvoxamine Maleate + Theophylline🟡Moderate

Potential interaction due to fluvoxamine inhibition of CYP1A2, which is involved in theophylline metabolism.

Fluvoxamine Maleate + Tizanidine🟡Moderate

Potential interaction due to fluvoxamine inhibition of CYP1A2, which is involved in tizanidine metabolism.

Fluvoxamine Maleate + Warfarin🟡Moderate

Potential interaction due to fluvoxamine inhibition of CYP1A2 and CYP2C9, which are involved in warfarin metabolism.

Fluvoxamine Maleate + Atenololℹ️Unknown

Coadministration of immediate-release fluvoxamine maleate tablets 100 mg per day with atenolol 100 mg per day (N=6) did not affect the plasma concentrations of atenolol. Unlike propranolol and metoprolol, which undergo hepatic metabolism, atenolol is eliminated primarily by renal excretion.

Fluvoxamine Maleate + Diazepamℹ️Unknown

Diazepam: See WARNINGS AND PRECAUTIONS ( 5.9 ).

Fluvoxamine Maleate + Ketoconazoleℹ️Unknown

The metabolism of fluvoxamine has not been fully characterized and the effects of potent cytochrome P450 isoenzyme inhibition, such as the ketoconazole inhibition of CYP3A4, on fluvoxamine metabolism have not been studied.

Fluvoxamine Maleate + Lorazepamℹ️Unknown

Lorazepam : A study of multiple doses of immediate-release fluvoxamine maleate tablets (50 mg given twice daily) in healthy male volunteers (N=12) and a single dose of lorazepam (4 mg single dose) indicated no significant pharmacokinetic interaction. On average, both lorazepam alone and lorazepam with fluvoxamine produced substantial decrements in cognitive functioning; however, the coadministration of fluvoxamine and lorazepam did not produce larger mean decrements compared to lorazepam alone.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.