Probenecid may decrease renal tubular secretion of cephalosporins, resulting in increased and more prolonged cephalosporin blood levels.
Source: NLP:cefazolin sodium
Brand names: Cefazolin
Route: Intravenous
FDA Black Box Warning
PHARMACY BULK PACKAGE – NOT FOR DIRECT INFUSION
Contraindications
CONTRAINDICATIONS: CEFAZOLIN FOR INJECTION IS CONTRAINDICATED IN PATIENTS WITH KNOWN ALLERGY TO THE CEPHALOSPORIN GROUP OF ANTIBIOTICS.
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects Pregnancy Category B. Reproduction studies have been performed in rats, mice, and rabbits at doses up to 25 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to Cefazolin for Injection. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
1 interaction on record
Probenecid may decrease renal tubular secretion of cephalosporins, resulting in increased and more prolonged cephalosporin blood levels.
Source: NLP:cefazolin sodium