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Disopyramide Phosphate

Also known as: Disopyramide Phosphate

Route: Oral

Check Disopyramide Phosphate Interactions →

12 interactions on record⛔ Black Box Warning

Disopyramide Phosphate has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clarithromycin, Erythromycin, Verapamil. Patients taking Disopyramide Phosphate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 3
Major: 7
Moderate: 1

Contraindicated (3)

Disopyramide Phosphate + Clarithromycin— Cases of life-threatening interactions have been reported. Clarithromycin inhibits cytochrome P450 3A4, resulting in ele…
Disopyramide Phosphate + Erythromycin— Cases of life-threatening interactions have been reported. Erythromycin inhibits cytochrome P450 3A4, resulting in eleva…
Disopyramide Phosphate + Verapamil— Do not administer disopyramide within 48 hours before or 24 hours after verapamil due to potential serious interactions.

Major (7)

Disopyramide Phosphate + Disopyramide— Drug Interactions If phenytoin or other hepatic enzyme inducers are taken concurrently with disopyramide phosphate, lowe…
Disopyramide Phosphate + Ketoconazole— Potent CYP3A4 inhibitor may result in potentially fatal interaction with disopyramide.
Disopyramide Phosphate + Lidocaine— Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation.
Disopyramide Phosphate + Oleandomycin— In vitro studies show oleandomycin inhibits disopyramide metabolism; coadministration with CYP3A4 inhibitors could resul…
Disopyramide Phosphate + Procainamide— Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation.
Disopyramide Phosphate + Propranolol— Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation, though no significant interactio…
Disopyramide Phosphate + Quinidine— Concurrent use may cause excessive QRS widening and/or Q-T prolongation. Slight increases in disopyramide levels and dec…

Moderate (1)

Disopyramide Phosphate + Phenytoin— Hepatic enzyme induction may lower plasma levels of disopyramide, potentially reducing effectiveness. Monitoring of diso…

Disopyramide Phosphate + Clarithromycin⛔Contraindicated

Cases of life-threatening interactions have been reported. Clarithromycin inhibits cytochrome P450 3A4, resulting in elevation of disopyramide plasma levels.

Disopyramide Phosphate + Erythromycin⛔Contraindicated

Cases of life-threatening interactions have been reported. Erythromycin inhibits cytochrome P450 3A4, resulting in elevation of disopyramide plasma levels.

Disopyramide Phosphate + Verapamil⛔Contraindicated

Do not administer disopyramide within 48 hours before or 24 hours after verapamil due to potential serious interactions.

Disopyramide Phosphate + Disopyramide⚠️Major

Drug Interactions If phenytoin or other hepatic enzyme inducers are taken concurrently with disopyramide phosphate, lower plasma levels of disopyramide may occur. Monitoring of disopyramide plasma levels is recommended in such concurrent use to avoid ineffective therapy. Other antiarrhythmic drugs (e.g., quinidine, procainamide, lidocaine, propranolol) have occasionally been used concurrently with disopyramide phosphate.

Disopyramide Phosphate + Ketoconazole⚠️Major

Potent CYP3A4 inhibitor may result in potentially fatal interaction with disopyramide.

Disopyramide Phosphate + Lidocaine⚠️Major

Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation.

Disopyramide Phosphate + Oleandomycin⚠️Major

In vitro studies show oleandomycin inhibits disopyramide metabolism; coadministration with CYP3A4 inhibitors could result in potentially fatal interaction.

Disopyramide Phosphate + Procainamide⚠️Major

Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation.

Disopyramide Phosphate + Propranolol⚠️Major

Concurrent antiarrhythmic use may cause excessive QRS widening and/or Q-T prolongation, though no significant interaction observed in healthy subjects.

Disopyramide Phosphate + Quinidine⚠️Major

Concurrent use may cause excessive QRS widening and/or Q-T prolongation. Slight increases in disopyramide levels and decreases in quinidine levels observed.

Disopyramide Phosphate + Phenytoin🟡Moderate

Hepatic enzyme induction may lower plasma levels of disopyramide, potentially reducing effectiveness. Monitoring of disopyramide plasma levels recommended.

Disopyramide Phosphate + Diazepamℹ️Unknown

In healthy subjects, no significant drug-drug interaction was observed when disopyramide phosphate was coadministered with either propranolol or diazepam.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.