Prazosin Hydrochloride has 25 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Acidifying Agents, Diuretic. Patients taking Prazosin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 25
- Major
- 1
- Moderate
- 4
- Minor
- 19
Major (1)
- Prazosin Hydrochloride + Mao Inhibitors— Concomitant administration can result in additive blood pressure lowering effects and symptomatic hypotension.
Moderate (4)
- Prazosin Hydrochloride + Acidifying Agents— Addition of other antihypertensive agents to prazosin causes additive hypotensive effect. Introduce cautiously and retit…
- Prazosin Hydrochloride + Diuretic— Addition of diuretics to prazosin hydrochloride causes additive hypotensive effect; dose reduction and cautious titratio…
- Prazosin Hydrochloride + Diuretics— Addition of a diuretic to prazosin causes additive hypotensive effect requiring dose adjustment and careful titration.
- Prazosin Hydrochloride + Propranolol— Administered without adverse drug interaction in limited clinical experience; however, caution noted in warnings.
Minor (19)
- Prazosin Hydrochloride + Acetylsalicylic Acid— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Allopurinol— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Chlordiazepoxide— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Chlorpropamide— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Colchicine— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Diazepam— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Digitalis Glycosides— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Digoxin— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Indomethacin— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Insulin Human— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Phenformin— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Phenobarbital— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Phenylbutazone— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Probenecid— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Procainamide— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Propoxyphene— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Quinidine— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Tolazamide— Administered without adverse drug interaction in limited clinical experience.
- Prazosin Hydrochloride + Tolbutamide— Administered without adverse drug interaction in limited clinical experience.