May interfere with ursodiol absorption by adsorbing bile acids, similar to bile acid sequestering agents.
Source: NLP:ursosiol
Ursosiol Interactions
Brand names: Ursodiol
Route: Oral
Contraindications
CONTRAINDICATIONS Ursodiol capsules will not dissolve calcified cholesterol stones, radiopaque stones, or radiolucent bile pigment stones. Hence, patients with such stones are not candidates for ursodiol capsules therapy. Patients with compelling reasons for cholecystectomy including unremitting acute cholecystitis, cholangitis, biliary obstruction, gallstone pancreatitis, or biliary-gastrointestinal fistula are not candidates for ursodiol capsules therapy. Allergy to bile acids.
Pregnancy & Breastfeeding
Pregnancy Category B Reproduction studies have been performed in rats and rabbits with ursodiol doses up to 200-fold the therapeutic dose and have revealed no evidence of impaired fertility or harm to the fetus at doses of 20- to 100-fold the human dose in rats and at 5-fold the human dose (highest dose tested) in rabbits. Studies employing 100- to 200-fold the human dose in rats have shown some reduction in fertility rate and litter size. There have been no adequate and well-controlled studies of the use of ursodiol in pregnant women, but inadvertent exposure of 4 women to therapeutic doses of the drug in the first trimester of pregnancy during the ursodiol capsules trials led to no evidence of effects on the fetus or newborn baby. Although it seems unlikely, the possibility that ursodiol can cause fetal harm cannot be ruled out; hence, the drug is not recommended for use during pregnancy.
6 interactions on record
Ursosiol + Cholestyramine LightModerate
Bile acid sequestering agent may interfere with ursodiol absorption and reduce its effectiveness.
Source: NLP:ursosiol
Ursosiol + ClofibrateModerate
Increases hepatic cholesterol secretion and encourages cholesterol gallstone formation, potentially counteracting ursodiol effectiveness.
Source: NLP:ursosiol
Ursosiol + ColestipolModerate
Bile acid sequestering agent may interfere with ursodiol absorption and reduce its effectiveness.
Source: NLP:ursosiol
Ursosiol + EstrogensModerate
Increase hepatic cholesterol secretion and encourage cholesterol gallstone formation, potentially counteracting ursodiol effectiveness.
Source: NLP:ursosiol
Ursosiol + Oral ContraceptivesModerate
Increase hepatic cholesterol secretion and encourage cholesterol gallstone formation, potentially counteracting ursodiol effectiveness.
Source: NLP:ursosiol