Elagolix has 7 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rifampin, Digoxin, Ethinyl Estradiol. Patients taking Elagolix should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 1
- Moderate
- 6
Major (1)
- Elagolix + Rifampin— Strong CYP3A inducer. Concomitant use with elagolix 200 mg twice daily is not recommended; limit with 150 mg once daily …
Moderate (6)
- Elagolix + Digoxin— Elagolix increases digoxin plasma concentrations. Monitor digoxin concentrations and signs of toxicity when initiating o…
- Elagolix + Ethinyl Estradiol— Elagolix increases ethinyl estradiol plasma concentrations. Use effective non-hormonal contraception during treatment an…
- Elagolix + Levonorgestrel— Elagolix decreases levonorgestrel plasma concentrations. Use effective non-hormonal contraception during treatment and f…
- Elagolix + Midazolam— Elagolix decreases midazolam plasma concentrations. Consider increasing midazolam dose by no more than 2-fold.
- Elagolix + Omeprazole— Elagolix increases omeprazole plasma concentrations. No dose adjustment needed for 40 mg once daily; consider dosage red…
- Elagolix + Rosuvastatin— Statins: rosuvastatin ↓ rosuvastatin Monitor lipid levels and adjust the dose of rosuvastatin, if necessary.