Stiripentol has 20 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alcohol, Caffeine, Cannabidiol. Patients taking Stiripentol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Moderate
- 20
Moderate (20)
- Stiripentol + Alcohol— Concomitant use of DIACOMIT with alcohol may increase the risk of sedation and somnolence.
- Stiripentol + Caffeine— Stiripentol is an inhibitor and inducer of CYP1A2; consider dose adjustment of caffeine when administered concomitantly …
- Stiripentol + Cannabidiol— Concomitant use increases plasma exposures of stiripentol. Monitor for stiripentol-related adverse reactions.
- Stiripentol + Carbamazepine— DIACOMIT may inhibit P-glycoprotein transport of carbamazepine; consider dose reduction if adverse reactions occur. Carb…
- Stiripentol + Clobazam— DIACOMIT increases plasma concentration of clobazam and its active metabolite norclobazam through inhibition of CYP3A4 a…
- Stiripentol + Clopidogrel— DIACOMIT may inhibit CYP2C19 metabolism of clopidogrel; consider dose reduction if adverse reactions occur.
- Stiripentol + Diazepam— DIACOMIT may inhibit CYP2C19 metabolism of diazepam; consider dose reduction if adverse reactions occur.
- Stiripentol + Fenfluramine— Coadministration increases fenfluramine plasma concentrations. Dose adjustment required; maximum daily dosage of FINTEPL…
- Stiripentol + Glibenclamide— DIACOMIT may inhibit BCRP transport of glyburide; consider dose reduction if adverse reactions occur.
- Stiripentol + Methotrexate— DIACOMIT may inhibit BCRP transport of methotrexate; consider dose reduction if adverse reactions occur.
- Stiripentol + Midazolam— Stiripentol is an inhibitor and inducer of CYP3A4; consider dose adjustment of midazolam when administered concomitantly…
- Stiripentol + Phenobarbital— Phenobarbital is a strong inducer of CYP1A2, CYP3A4, and CYP2C19 and may decrease DIACOMIT concentrations. Concomitant u…
- Stiripentol + Phenytoin— Phenytoin is a strong inducer of CYP1A2, CYP3A4, and CYP2C19 and may decrease DIACOMIT concentrations. Concomitant use s…
- Stiripentol + Prazosin— DIACOMIT may inhibit BCRP transport of prazosin; consider dose reduction if adverse reactions occur.
- Stiripentol + Quinidine— Stiripentol is an inhibitor and inducer of CYP3A4; consider dose adjustment of quinidine when administered concomitantly…
- Stiripentol + Rifampin— Rifampin is a strong inducer of CYP1A2, CYP3A4, and CYP2C19 and may decrease DIACOMIT concentrations. Concomitant use sh…
- Stiripentol + Sertraline— Stiripentol is an inhibitor and inducer of CYP2B6; consider dose adjustment of sertraline when administered concomitantl…
- Stiripentol + Theophylline— Stiripentol is an inhibitor and inducer of CYP1A2; consider dose adjustment of theophylline when administered concomitan…
- Stiripentol + Thiotepa— Stiripentol is an inhibitor and inducer of CYP2B6; consider dose adjustment of thiotepa when administered concomitantly …
- Stiripentol + Triazolam— Stiripentol is an inhibitor and inducer of CYP3A4; consider dose adjustment of triazolam when administered concomitantly…