Doravirine has 23 known drug interactions based on U.S. FDA drug labeling data. Of these, 9 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Enzalutamide, Mitotane. Patients taking Doravirine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Contraindicated
- 9
- Major
- 4
Contraindicated (9)
- Doravirine + Carbamazepine— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Enzalutamide— Androgen Receptors enzalutamide ↓ doravirine Co-administration is contraindicated with enzalutamide.
- Doravirine + Mitotane— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Oxcarbazepine— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Phenobarbital— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Phenytoin— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Rifampin— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + Rifapentine— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
- Doravirine + St. John'S Wort— Co-administration decreases doravirine plasma concentrations. At least a 4-week cessation period is recommended prior to…
Major (4)
- Doravirine + Efavirenz— Co-administration decreases doravirine plasma concentrations. Use with efavirenz is not recommended.
- Doravirine + Etravirine— Co-administration decreases doravirine plasma concentrations. Use with etravirine is not recommended.
- Doravirine + Nevirapine— Co-administration decreases doravirine plasma concentrations. Use with nevirapine is not recommended.
- Doravirine + Rifabutin— Co-administration decreases doravirine plasma concentrations. Increase PIFELTRO dosage to one tablet twice daily when co…