Sarecycline Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acitretin, Isotretinoin, Penicillin. Patients taking Sarecycline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 3
- Major
- 1
- Moderate
- 6
Contraindicated (3)
- Sarecycline Hydrochloride + Acitretin— Tetracyclines and oral retinoids both may cause increased intracranial pressure. Avoid coadministration.
- Sarecycline Hydrochloride + Isotretinoin— Tetracyclines and oral retinoids both may cause increased intracranial pressure. Avoid coadministration.
- Sarecycline Hydrochloride + Penicillin— SEYSARA may interfere with the bactericidal action of penicillin. Avoid coadministration.
Major (1)
- Sarecycline Hydrochloride + Oral Anticoagulants— SEYSARA may depress plasma prothrombin activity, increasing bleeding risk. Decrease anticoagulant dosage as appropriate.
Moderate (6)
- Sarecycline Hydrochloride + Antacids Containing Aluminum— Coadministration may impair SEYSARA absorption and decrease efficacy. Separate dosing required.
- Sarecycline Hydrochloride + Antacids Containing Magnesium— Coadministration may impair SEYSARA absorption and decrease efficacy. Separate dosing required.
- Sarecycline Hydrochloride + Bismuth Subsalicylate— Coadministration may impair SEYSARA absorption and decrease efficacy. Separate dosing required.
- Sarecycline Hydrochloride + Calcium Antagonists— Coadministration may impair SEYSARA absorption and decrease efficacy. Separate dosing required.
- Sarecycline Hydrochloride + Digoxin— SEYSARA may increase digoxin concentrations as a P-glycoprotein substrate. Monitor for toxicities and adjust dosage if n…
- Sarecycline Hydrochloride + Iron-Containing Preparations— Coadministration may impair SEYSARA absorption and decrease efficacy. Separate dosing required.