Chloroquine Phosphate has 12 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Cimetidine, Cyclosporine. Patients taking Chloroquine Phosphate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 6
- Moderate
- 6
Major (6)
- Chloroquine Phosphate + Amiodarone— Increased risk of inducing ventricular arrhythmias when used concomitantly with chloroquine.
- Chloroquine Phosphate + Cimetidine— Cimetidine inhibits metabolism of chloroquine, increasing plasma levels. Concomitant use should be avoided.
- Chloroquine Phosphate + Cyclosporine— Chloroquine can cause sudden increase in serum cyclosporine levels; close monitoring is recommended and chloroquine may …
- Chloroquine Phosphate + Mefloquine— Co-administration of chloroquine and mefloquine may increase the risk of convulsions.
- Chloroquine Phosphate + Moxifloxacin— Increased risk of inducing ventricular arrhythmias when used concomitantly with chloroquine.
- Chloroquine Phosphate + Tamoxifen— Concomitant use of chloroquine with tamoxifen is not recommended due to risk of retinal toxicity.
Moderate (6)
- Chloroquine Phosphate + Ampicillin— Chloroquine significantly reduces bioavailability of ampicillin; an interval of at least 2 hours between intake should b…
- Chloroquine Phosphate + Antacids Containing Calcium— Antacids can reduce absorption of chloroquine; an interval of at least 4 hours between intake should be observed.
- Chloroquine Phosphate + Insulin Human— Chloroquine may enhance hypoglycemic effects of insulin, requiring a decrease in insulin doses.
- Chloroquine Phosphate + Kaolin— Kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake should be observed.
- Chloroquine Phosphate + Praziquantel— Chloroquine reduces the bioavailability of praziquantel.
- Chloroquine Phosphate + Remdesivir— Potential antagonism based on cell culture data; concomitant use is not recommended due to risk of reduced efficacy.