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Talazoparib

Also known as: Talzenna

Route: Oral

7 interactions on record

Talazoparib has 7 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Carvedilol, Clarithromycin. Patients taking Talazoparib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 7
Major: 5
Moderate: 1

Major (5)

Talazoparib + Amiodarone— P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor …
Talazoparib + Carvedilol— P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor …
Talazoparib + Clarithromycin— ( 7.1 ) 7.1 Effect of Other Drugs on TALZENNA Effect of P-gp Inhibitors Breast Cancer Avoid coadministration of TALZENNA…
Talazoparib + Itraconazole— ( 7.1 ) 7.1 Effect of Other Drugs on TALZENNA Effect of P-gp Inhibitors Breast Cancer Avoid coadministration of TALZENNA…
Talazoparib + Verapamil— P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor …

Moderate (1)

Talazoparib + Mao Inhibitors— BCRP inhibitors may increase talazoparib exposure; monitor for increased adverse reactions and modify dosage as recommen…

Talazoparib + Amiodarone⚠️Major

P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor for increased adverse reactions.

Talazoparib + Carvedilol⚠️Major

P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor for increased adverse reactions.

Talazoparib + Clarithromycin⚠️Major

( 7.1 ) 7.1 Effect of Other Drugs on TALZENNA Effect of P-gp Inhibitors Breast Cancer Avoid coadministration of TALZENNA with the following P-gp inhibitors: itraconazole, amiodarone, carvedilol, clarithromycin, itraconazole, and verapamil.

Talazoparib + Itraconazole⚠️Major

Talazoparib + Verapamil⚠️Major

P-gp inhibitor that increases talazoparib concentrations; avoid coadministration or reduce talazoparib dose and monitor for increased adverse reactions.

Talazoparib + Mao Inhibitors🟡Moderate

BCRP inhibitors may increase talazoparib exposure; monitor for increased adverse reactions and modify dosage as recommended.

Talazoparib + Enzalutamideℹ️Unknown

HRR Gene-mutated mCRPC The effect of coadministration of P-gp inhibitors on talazoparib exposure when TALZENNA is taken with enzalutamide has not been studied.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.