Siponimod has 14 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alemtuzumab, Amiodarone, Digoxin. Patients taking Siponimod should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 12
- Moderate
- 2
Major (12)
- Siponimod + Alemtuzumab— Initiating treatment with siponimod after alemtuzumab is not recommended due to prolonged immune suppressive effects.
- Siponimod + Amiodarone— Class III antiarrhythmic associated with Torsades de Pointes in bradycardia patients; should generally not be initiated …
- Siponimod + Digoxin— Drug that may decrease heart rate; treatment with siponimod should generally not be initiated due to additive heart rate…
- Siponimod + Diltiazem— Heart-rate lowering calcium channel blocker; treatment with siponimod should generally not be initiated due to additive …
- Siponimod + Dual Strong Cyp3a4 / Moderate Cyp1a2 Inducers— Dual moderate CYP2C9/strong CYP3A4 inducers decrease siponimod exposure; concomitant use is not recommended.
- Siponimod + Ivabradine— Drug that may decrease heart rate; treatment with siponimod should generally not be initiated due to additive heart rate…
- Siponimod + Live Attenuated Vaccines— Avoid live-attenuated vaccines during and for up to 4 weeks after treatment with siponimod due to immunosuppressive effe…
- Siponimod + Mao Inhibitors— Strong CYP2C9 inhibitors increase siponimod exposure; concomitant use is not recommended.
- Siponimod + Procainamide— Class Ia antiarrhythmic associated with Torsades de Pointes in bradycardia patients; seek cardiologist advice before usi…
- Siponimod + Quinidine— Class Ia antiarrhythmic associated with Torsades de Pointes in bradycardia patients; seek cardiologist advice before usi…
- Siponimod + Sotalol— Class III antiarrhythmic associated with Torsades de Pointes in bradycardia patients; should generally not be initiated …
- Siponimod + Verapamil— Heart-rate lowering calcium channel blocker; treatment with siponimod should generally not be initiated due to additive …
Moderate (2)
- Siponimod + Cyp3a Inducers— Monitor for loss of efficacy with moderate or strong CYP3A4 inducers in patients with CYP2C9*1/*3 or *2/*3 genotypes.
- Siponimod + Nonselective Beta-Adrenergic Antagonists— Caution when initiating siponimod in patients on beta-blockers; temporary interruption may be needed due to additive hea…