Norgestimate And Ethinyl Estradiol has 46 known drug interactions based on U.S. FDA drug labeling data. 26 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amprenavir, Aprepitant, Atazanavir. Patients taking Norgestimate And Ethinyl Estradiol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 46
- Major
- 26
- Moderate
- 16
Major (26)
- Norgestimate And Ethinyl Estradiol + Amprenavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Aprepitant— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Atazanavir— HIV protease inhibitor that may increase plasma concentrations of estrogen and/or progestin.
- Norgestimate And Ethinyl Estradiol + Barbiturates— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Boceprevir— HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Bosentan— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Carbamazepine— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Darunavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Felbamate— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Fosamprenavir— HIV protease inhibitor combination that decreases plasma concentrations of estrogen and/or progestin, potentially dimini…
- Norgestimate And Ethinyl Estradiol + Griseofulvin— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Indinavir— HIV protease inhibitor that may increase plasma concentrations of estrogen and/or progestin.
- Norgestimate And Ethinyl Estradiol + Lopinavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Lopinavir And Ritonavir— HIV protease inhibitor combination that decreases plasma concentrations of estrogen and/or progestin, potentially dimini…
- Norgestimate And Ethinyl Estradiol + Nelfinavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Nevirapine— Non-nucleoside reverse transcriptase inhibitor that may significantly decrease plasma concentrations of estrogen and/or …
- Norgestimate And Ethinyl Estradiol + Oxcarbazepine— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Phenytoin— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Rifabutin— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Rifampin— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Ritonavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Rufinamide— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + St. John'S Wort— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
- Norgestimate And Ethinyl Estradiol + Telaprevir— HCV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Tipranavir— HIV protease inhibitor that may decrease plasma concentrations of estrogen and/or progestin, potentially reducing contra…
- Norgestimate And Ethinyl Estradiol + Topiramate— May decrease plasma concentrations of COCs and potentially diminish effectiveness or increase breakthrough bleeding.
Moderate (16)
- Norgestimate And Ethinyl Estradiol + Acetaminophen— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Norgestimate And Ethinyl Estradiol + Ascorbic Acid— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Norgestimate And Ethinyl Estradiol + Atorvastatin— Co-administration increases AUC of ethinyl estradiol by approximately 20-25%, potentially increasing hormone exposure.
- Norgestimate And Ethinyl Estradiol + Clofibrate— Norgestimate and ethinyl estradiol may decrease plasma concentrations of clofibrate.
- Norgestimate And Ethinyl Estradiol + Colesevelam— Bile acid sequestrant that significantly decreases AUC of ethinyl estradiol; separation of dosing by 4 hours may mitigat…
- Norgestimate And Ethinyl Estradiol + Cyclosporine— Ethinyl estradiol may inhibit the metabolism of cyclosporine and increase its plasma concentrations.
- Norgestimate And Ethinyl Estradiol + Etravirine— Non-nucleoside reverse transcriptase inhibitor that may increase plasma concentrations of estrogen and/or progestin, pot…
- Norgestimate And Ethinyl Estradiol + Fluconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of ethinyl estradiol and norgestimate.
- Norgestimate And Ethinyl Estradiol + Grapefruit Juice— CYP3A4 inhibitor that may increase plasma hormone concentrations of ethinyl estradiol and norgestimate.
- Norgestimate And Ethinyl Estradiol + Itraconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of ethinyl estradiol and norgestimate.
- Norgestimate And Ethinyl Estradiol + Ketoconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of ethinyl estradiol and norgestimate.
- Norgestimate And Ethinyl Estradiol + Prednisolone— Ethinyl estradiol may inhibit the metabolism of prednisolone and increase its plasma concentrations.
- Norgestimate And Ethinyl Estradiol + Rosuvastatin— Co-administration increases AUC of ethinyl estradiol by approximately 20-25%, potentially increasing hormone exposure.
- Norgestimate And Ethinyl Estradiol + Theophylline— Ethinyl estradiol may inhibit the metabolism of theophylline and increase its plasma concentrations.
- Norgestimate And Ethinyl Estradiol + Tizanidine— Ethinyl estradiol may inhibit the metabolism of tizanidine and increase its plasma concentrations.
- Norgestimate And Ethinyl Estradiol + Voriconazole— CYP3A4 inhibitor that may increase plasma hormone concentrations of ethinyl estradiol and norgestimate.