Irbesartan And Hydrochlorothiazide has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Angiotensin Ii, Carbamazepine. Patients taking Irbesartan And Hydrochlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 1
- Major
- 7
- Moderate
- 12
Contraindicated (1)
- Irbesartan And Hydrochlorothiazide + Aliskiren— Do not coadminister aliskiren with irbesartan and hydrochlorothiazide in patients with diabetes. Avoid in patients with …
Major (7)
- Irbesartan And Hydrochlorothiazide + Angiotensin Ii— Dual RAS blockade increases risk of hypotension, hyperkalemia, and acute renal failure. Combined use should generally be…
- Irbesartan And Hydrochlorothiazide + Carbamazepine— Carbamazepine increases risk of hyponatremia when used with irbesartan and hydrochlorothiazide.
- Irbesartan And Hydrochlorothiazide + Hydrochlorothiazide— Closely monitor blood pressure, renal function, and electrolytes in patients on irbesartan and hydrochlorothiazide table…
- Irbesartan And Hydrochlorothiazide + Lithium— Increased serum lithium concentrations and risk of lithium toxicity. Monitor lithium levels.
- Irbesartan And Hydrochlorothiazide + Mao Inhibitors— COX-2 inhibitors can reduce diuretic and antihypertensive effects, and may result in deterioration of renal function inc…
- Irbesartan And Hydrochlorothiazide + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIDs can reduce diuretic and antihypertensive effects, and may cause renal impairment including acute renal failure, e…
- Irbesartan And Hydrochlorothiazide + Nsaids— NSAIDs can reduce diuretic and natriuretic effects, and may lead to renal impairment and reduced antihypertensive effect…
Moderate (12)
- Irbesartan And Hydrochlorothiazide + Alcohol— Potentiation of orthostatic hypotension may occur.
- Irbesartan And Hydrochlorothiazide + Barbiturates— Potentiation of orthostatic hypotension may occur.
- Irbesartan And Hydrochlorothiazide + Cholestyramine Light— Reduced absorption of thiazides when coadministered with cholestyramine.
- Irbesartan And Hydrochlorothiazide + Colestipol— Reduced absorption of thiazides when coadministered with colestipol.
- Irbesartan And Hydrochlorothiazide + Corticosteroids— Intensified electrolyte depletion, particularly hypokalemia.
- Irbesartan And Hydrochlorothiazide + Insulin Degludec And Liraglutide— Dosage adjustment of antidiabetic drug may be required when coadministered with hydrochlorothiazide.
- Irbesartan And Hydrochlorothiazide + Insulin Human— Dosage adjustment of insulin may be required when coadministered with hydrochlorothiazide.
- Irbesartan And Hydrochlorothiazide + Irbesartan— ( 7 ) 7.1 Nonsteroidal Anti-inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) Irbes…
- Irbesartan And Hydrochlorothiazide + Norepinephrine— Possible decreased response to pressor amines but not sufficient to preclude their use.
- Irbesartan And Hydrochlorothiazide + Other Anticholinergic Agents— Additive effect or potentiation of antihypertensive response may occur.
- Irbesartan And Hydrochlorothiazide + Repository Corticotropin— Intensified electrolyte depletion, particularly hypokalemia.
- Irbesartan And Hydrochlorothiazide + Tubocurarine— Possible increased responsiveness to nondepolarizing skeletal muscle relaxant.