Azole Antifungals has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Amiodarone Hydrochloride, Pimozide, Amlodipine And Atorvastatin. Patients taking Azole Antifungals should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 2
- Moderate
- 7
Contraindicated (2)
- Azole Antifungals + Amiodarone Hydrochloride— Increased risk of Torsades de Pointes and increased amiodarone exposure. Avoid concomitant use.
- Azole Antifungals + Pimozide— Pimozide should not be administered concomitantly with azole antifungal agents as inhibitors of CYP 3A4 metabolism.
Moderate (7)
- Azole Antifungals + Amlodipine And Atorvastatin— Consider risk/benefit of concomitant use with atorvastatin due to increased myopathy risk.
- Azole Antifungals + Atorvastatin Calcium— Consider risk/benefit of concomitant use with atorvastatin due to increased myopathy/rhabdomyolysis risk.
- Azole Antifungals + Carbamazepine— CYP3A4 inhibitors that may increase plasma levels of carbamazepine; dose reduction may be necessary.
- Azole Antifungals + Clonazepam— Cytochrome P-450 3A inhibitors that may increase clonazepam levels; should be used cautiously in patients receiving clon…
- Azole Antifungals + Dichlorphenamide— Increased risk of hypokalemia with coadministration of dichlorphenamide and antifungals.
- Azole Antifungals + Mirtazapine— Azole antifungals are potent CYP3A4 inhibitors that may increase mirtazapine concentrations. Caution should be exercised…
- Azole Antifungals + Quizartinib— QT interval prolonging drugs. Coadministration with VANFLYTA may further increase incidence of QT prolongation. More fre…