Cyclobenzaprine + Mao InhibitorsContraindicated
Life-threatening interaction with MAO inhibitors; contraindicated use.
Source: NLP:cyclobenzaprine
Cyclobenzaprine Interactions
Brand names: Cyclobenzaprine Hydrochloride
Route: Oral
Contraindications
CONTRAINDICATIONS Hypersensitivity to any component of this product. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. Hyperthyroidism.
Pregnancy & Breastfeeding
Pregnancy Pregnancy Category B: Reproduction studies have been performed in rats, mice and rabbits at doses up to 20 times the human dose, and have revealed no evidence of impaired fertility or harm to the fetus due to cyclobenzaprine HCl. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
17 interactions on record
Cyclobenzaprine + Safinamide MesylateContraindicated
Skeletal muscle relaxant with tricyclic antidepressant derivative properties; concomitant use is contraindicated due to serotonergic effects.
Source: NLP:safinamide mesylate
Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
Source: NLP:cyclobenzaprine
Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjustment.
Source: NLP:hydromorphone hydrochloride
Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
Source: NLP:cyclobenzaprine
Muscle relaxant that can result in serotonin syndrome when used concomitantly. Requires frequent patient evaluation.
Source: NLP:morphine sulfate
Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment.
Source: NLP:nalbuphine hydrochloride
Muscle relaxant and CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death when used concomitantly.
Source: NLP:oxycodone and acetaminophen
Serotonergic muscle relaxant that may result in serotonin syndrome when used concomitantly.
Source: NLP:oxymorphone hydrochloride
Concomitant use may result in serotonin syndrome.
Source: NLP:remifentanil hydrochloride
Serotonergic activity and CNS depression increase risk of serotonin syndrome and respiratory depression.
Source: NLP:tapentadol hydrochloride
Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
Source: NLP:cyclobenzaprine
Postmarketing cases of serotonin syndrome reported; tricyclic antidepressants may enhance seizure risk.
Source: NLP:cyclobenzaprine
Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
Source: NLP:cyclobenzaprine
Cyclobenzaprine + AlcoholModerate
Cyclobenzaprine may enhance the effects of alcohol and CNS depression.
Source: NLP:cyclobenzaprine
Cyclobenzaprine + BarbituratesModerate
Cyclobenzaprine may enhance the effects of barbiturates and CNS depression.
Source: NLP:cyclobenzaprine
Cyclobenzaprine + GuanethidineModerate
Tricyclic antidepressants may block the antihypertensive action of guanethidine.
Source: NLP:cyclobenzaprine