Cyclobenzaprine has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Oxycodone And Acetaminophen, Safinamide Mesylate. Patients taking Cyclobenzaprine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 3
- Major
- 12
- Moderate
- 5
Contraindicated (3)
- Cyclobenzaprine + Mao Inhibitors— Life-threatening interaction with MAO inhibitors; contraindicated use.
- Cyclobenzaprine + Oxycodone And Acetaminophen— Muscle relaxant CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and …
- Cyclobenzaprine + Safinamide Mesylate— Skeletal muscle relaxant with tricyclic antidepressant derivative properties; concomitant use is contraindicated due to …
Major (12)
- Cyclobenzaprine + Bupropion— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
- Cyclobenzaprine + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
- Cyclobenzaprine + Levorphanol Tartrate— Can result in serotonin syndrome and increased respiratory depression. Enhance neuromuscular blocking action.
- Cyclobenzaprine + Meperidine— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
- Cyclobenzaprine + Morphine Sulfate— Muscle relaxant that can result in serotonin syndrome when used concomitantly. Requires frequent patient evaluation.
- Cyclobenzaprine + Nalbuphine Hydrochloride— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustm…
- Cyclobenzaprine + Oxymorphone Hydrochloride— Serotonergic muscle relaxant that may result in serotonin syndrome when used concomitantly.
- Cyclobenzaprine + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
- Cyclobenzaprine + Tapentadol Hydrochloride— Serotonergic activity and CNS depression increase risk of serotonin syndrome and respiratory depression.
- Cyclobenzaprine + Tcas— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
- Cyclobenzaprine + Tramadol— Postmarketing cases of serotonin syndrome reported; tricyclic antidepressants may enhance seizure risk.
- Cyclobenzaprine + Verapamil— Postmarketing cases of serotonin syndrome reported during combined use; careful observation advised.
Moderate (5)
- Cyclobenzaprine + Alcohol— Cyclobenzaprine may enhance the effects of alcohol and CNS depression.
- Cyclobenzaprine + Barbiturates— Cyclobenzaprine may enhance the effects of barbiturates and CNS depression.
- Cyclobenzaprine + Butorphanol Tartrate— Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.
- Cyclobenzaprine + Guanethidine— Tricyclic antidepressants may block the antihypertensive action of guanethidine.
- Cyclobenzaprine + Pentazocine Hydrochloride And Naloxone Hydrochloride— Muscle relaxant affecting serotonergic system may cause serotonin syndrome; careful observation required.