Triptans has 51 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 34 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Almotriptan Malate, Dihydroergotamine Mesylate, Frovatriptan Succinate. Patients taking Triptans should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 51
- Contraindicated
- 8
- Major
- 34
- Moderate
- 9
Contraindicated (8)
- Triptans + Almotriptan Malate— Concomitant use of other 5-HT1 agonists (triptans) within 24 hours of almotriptan malate is contraindicated.
- Triptans + Dihydroergotamine Mesylate— Serotonin 5-HT1B/1D receptor agonists; additive coronary artery vasospasm risk; do not use within 24 hours of each other…
- Triptans + Frovatriptan Succinate— Other 5-HT1B/1D agonists have additive vasospastic effects with frovatriptan. Co-administration within 24 hours of each …
- Triptans + Naratriptan— Other 5-HT1B/1D agonists (triptans) contraindicated within 24 hours of naratriptan due to risk of additive vasospastic r…
- Triptans + Sumatriptan— Other 5-HT1 agonists (triptans) have additive vasospastic effects with sumatriptan. Coadministration within 24 hours of …
- Triptans + Sumatriptan Succinate— Other 5-HT1 agonists (triptans) have additive vasospastic effects; contraindicated within 24 hours of sumatriptan succin…
- Triptans + Sumatriptan Succinate And Naproxen Sodium— Other 5-HT1 agonists can cause vasospastic effects. Coadministration within 24 hours is contraindicated due to additive …
- Triptans + Zolmitriptan— Other 5-HT1B/1D agonists including triptans contraindicated within 24 hours due to risk of additive vasospastic reaction…
Major (34)
- Triptans + Atropa Belladonna And Opium— Concomitant use may result in serotonin syndrome. Patient requires careful observation, particularly during initiation a…
- Triptans + Citalopram— Rare postmarketing reports of serotonin syndrome with concurrent use of citalopram and triptans. Careful observation adv…
- Triptans + Citalopram Hydrobromide— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
- Triptans + Desvenlafaxine Succinate— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Triptans + Dextroamphetamine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome occurs.
- Triptans + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Concomitant use increases the risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation…
- Triptans + Dextroamphetamine Sulfate— Serotonergic drugs that increase risk of serotonin syndrome with dextroamphetamine sulfate.
- Triptans + Droxidopa— Concomitant use may increase risk for supine hypertension due to additive blood pressure-raising effects.
- Triptans + Escitalopram— Rare postmarketing reports of serotonin syndrome with SSRIs and triptans. Careful observation advised if concomitant use…
- Triptans + Escitalopram Oxalate— Rare postmarketing reports of serotonin syndrome with SSRIs and triptans. Careful observation advised during treatment i…
- Triptans + Fluoxetine— Increases risk of serotonin syndrome. Monitor patients for signs and symptoms during treatment initiation and dosage inc…
- Triptans + Fluoxetine Hydrochloride— Concomitant use increases risk of serotonin syndrome; monitor for symptoms.
- Triptans + Hydrocodone Bitartrate And Acetaminophen— Concomitant use has resulted in serotonin syndrome; carefully observe patient during treatment initiation and dose adjus…
- Triptans + Hydromorphone Hydrochloride— Concomitant use may result in serotonin syndrome. Frequently evaluate patient during treatment initiation and dose adjus…
- Triptans + Levorphanol Tartrate— Concomitant use has resulted in serotonin syndrome.
- Triptans + Metaxalone— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dosage modif…
- Triptans + Milnacipran Hydrochloride— Rare postmarketing reports of serotonin syndrome. Careful observation advised if concomitant treatment is clinically war…
- Triptans + Mirtazapine— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during treatment init…
- Triptans + Morphine Sulfate— Concomitant use can result in serotonin syndrome. Requires frequent patient evaluation, particularly during initiation a…
- Triptans + Nalbuphine Hydrochloride— Concomitant use may result in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustm…
- Triptans + Oxymorphone Hydrochloride— Concomitant use with serotonergic drugs has resulted in serotonin syndrome.
- Triptans + Paroxetine— Concomitant use of serotonergic drugs triptans with paroxetine increases risk of serotonin syndrome.
- Triptans + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjus…
- Triptans + Remifentanil Hydrochloride— Concomitant use may result in serotonin syndrome.
- Triptans + Sertraline— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initi…
- Triptans + Sertraline Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during treat…
- Triptans + Tapentadol Hydrochloride— Concomitant use may result in serotonin syndrome. Frequent patient evaluation is recommended during initiation and dose …
- Triptans + Trazodone Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms during trazodone initiatio…
- Triptans + Venlafaxine— Potential for serotonin syndrome with serotonergic drugs including triptans. Careful patient observation advised.
- Triptans + Venlafaxine Hcl Er— Potential for serotonin syndrome when used with serotonergic drugs. Careful patient observation advised.
- Triptans + Venlafaxine Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Triptans + Ziprasidone— Risk of serotonin syndrome with concomitant therapy with triptans.
- Triptans + Ziprasidone Hcl— Risk of serotonin syndrome with concomitant serotonergic therapy including triptans.
- Triptans + Ziprasidone Mesylate— Risk of serotonin syndrome with concomitant serotonergic therapy including triptans.
Moderate (9)
- Triptans + Butorphanol Tartrate— Concomitant use may result in serotonin syndrome; monitor regularly during initiation and dose adjustment.
- Triptans + Desvenlafaxine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Triptans + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms and consider discontinuation if serotonin syn…
- Triptans + Duloxetine— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms during treatment initiation and dose increase…
- Triptans + Levomilnacipran Hydrochloride— Serotonergic drugs that increase risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Triptans + Paroxetine Hydrochloride— Concomitant use of serotonergic drugs with paroxetine increases the risk of serotonin syndrome. Monitor for symptoms.
- Triptans + Paroxetine Hydrochloride Hemihydrate— Rare postmarketing reports of serotonin syndrome. Careful observation advised if concomitant use is clinically warranted…
- Triptans + Vilazodone Hydrochloride— Serotonergic drugs that increase risk of serotonin syndrome; monitor patients for signs and symptoms during initiation.
- Triptans + Vortioxetine— Serotonergic drugs that increase risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…