Quetiapine Fumarate has 13 known drug interactions based on U.S. FDA drug labeling data. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Carbamazepine, Indinavir. Patients taking Quetiapine Fumarate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Major
- 10
- Moderate
- 3
Major (10)
- Quetiapine Fumarate + Alcohol— Alcohol potentiates cognitive and motor effects of quetiapine. Alcoholic beverages should be limited while taking quetia…
- Quetiapine Fumarate + Carbamazepine— Potent CYP3A4 inducer that decreases quetiapine exposure; dose adjustment necessary.
- Quetiapine Fumarate + Indinavir— Potent CYP3A4 inhibitor that increases quetiapine exposure; dose adjustment necessary.
- Quetiapine Fumarate + Itraconazole— Potent CYP3A4 inhibitor that increases quetiapine exposure; dose adjustment necessary.
- Quetiapine Fumarate + Ketoconazole— Strong CYP3A4 inhibitor that significantly increases quetiapine exposure; quetiapine dose should be reduced to one sixth…
- Quetiapine Fumarate + Nefazodone— Potent CYP3A4 inhibitor that increases quetiapine exposure; dose adjustment necessary.
- Quetiapine Fumarate + Phenytoin— Strong CYP3A4 inducer that increases quetiapine clearance 5-fold; quetiapine dose may need to be increased up to 5 fold.
- Quetiapine Fumarate + Rifampin— Strong CYP3A4 inducer that decreases quetiapine exposure; quetiapine dose may need to be increased up to 5 fold.
- Quetiapine Fumarate + Ritonavir— Strong CYP3A4 inhibitor that increases quetiapine exposure; quetiapine dose should be reduced to one sixth of original d…
- Quetiapine Fumarate + St. John'S Wort— Strong CYP3A4 inducer that decreases quetiapine exposure; quetiapine dose may need to be increased up to 5 fold.
Moderate (3)
- Quetiapine Fumarate + Acidifying Agents— Quetiapine may enhance the effects of antihypertensive agents due to its potential for inducing hypotension.
- Quetiapine Fumarate + Dopamine Agonists— Quetiapine may antagonize the effects of dopamine agonists.
- Quetiapine Fumarate + Levodopa— Quetiapine may antagonize the effects of levodopa.