Lasmiditan has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Digoxin, Alcohol, Dextromethorphan. Patients taking Lasmiditan should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 1
- Moderate
- 7
Contraindicated (1)
- Lasmiditan + Digoxin— Coadministration not recommended due to risk of serious toxicities from increased digoxin plasma concentration.
Moderate (7)
- Lasmiditan + Alcohol— Concomitant use may enhance CNS depression and cognitive/neuropsychiatric effects; use with caution.
- Lasmiditan + Dextromethorphan— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Lasmiditan + Mao Inhibitors— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Lasmiditan + Propranolol— Lasmiditan addition to propranolol caused additional 5 bpm heart rate decrease; use with caution in patients where this …
- Lasmiditan + St. John'S Wort— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Lasmiditan + Tcas— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.
- Lasmiditan + Trazodone— Increased risk of serotonin syndrome when combined with lasmiditan; use with caution.