Depo-Medrol, Lidocaine, Isopropyl Alcohol has 22 known drug interactions based on U.S. FDA drug labeling data. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Aminoglutethimide, Amphotericin B. Patients taking Depo-Medrol, Lidocaine, Isopropyl Alcohol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Major
- 11
- Moderate
- 11
Major (11)
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Acetylsalicylic Acid— Concomitant use with corticosteroids increases risk of gastrointestinal side effects. Use cautiously in hypoprothrombine…
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Aminoglutethimide— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Amphotericin B— Concomitant use with corticosteroids may cause hypokalemia and has been associated with cardiac enlargement and congesti…
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Anticholinesterase Agents— Concomitant use may produce severe weakness in patients with myasthenia gravis.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Cyclosporine— Increased activity of both cyclosporine and corticosteroids may occur concurrently, with convulsions reported.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Digitalis Glycosides— Patients may be at risk of arrhythmias due to hypokalemia induced by corticosteroids.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Erythromycin— Erythromycin inhibits cytochrome P450 3A4, resulting in increased plasma concentrations of corticosteroids.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Ketoconazole— Ketoconazole significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of side effects.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Macrolide Antibiotics— Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid levels.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Concomitant use with corticosteroids increases risk of gastrointestinal side effects.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Troleandomycin— Troleandomycin inhibits cytochrome P450 3A4, resulting in increased plasma concentrations of corticosteroids.
Moderate (11)
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Acidifying Agents— Corticosteroids may increase blood glucose concentration, requiring dosage adjustments of antidiabetic agents.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Barbiturates— Barbiturates induce CYP3A4 enzyme activity, enhancing corticosteroid metabolism and requiring dose increases.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Carbamazepine— Carbamazepine induces CYP3A4 enzyme activity, enhancing corticosteroid metabolism and requiring dose increases.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Cholestyramine Light— Cholestyramine may increase the clearance of oral corticosteroids.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Estrogens— Estrogens may decrease hepatic metabolism of certain corticosteroids, increasing their effect.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Isoniazid— Serum concentrations of isoniazid may be decreased by corticosteroids.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of corticosteroids, thereby increasing their effect.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Phenytoin— Phenytoin induces CYP3A4 enzyme activity, enhancing corticosteroid metabolism and requiring dose increases.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Rifampin— Rifampin induces CYP3A4 enzyme activity, enhancing corticosteroid metabolism and requiring dose increases.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Salicylates— Clearance of salicylates may be increased by corticosteroids.
- Depo-Medrol, Lidocaine, Isopropyl Alcohol + Warfarin— Co-administration usually results in inhibition of warfarin response; coagulation indices should be monitored frequently…