Leucovorin Calcium has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Sulfamethoxazole And Trimethoprim, Fluorouracil, Sulfamethoxazole. Patients taking Leucovorin Calcium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 1
- Major
- 2
- Moderate
- 5
Contraindicated (1)
- Leucovorin Calcium + Sulfamethoxazole And Trimethoprim— Avoid concomitant use. Leucovorin decreases effectiveness of trimethoprim-sulfamethoxazole, associated with increased tr…
Major (2)
- Leucovorin Calcium + Fluorouracil— Leucovorin may enhance the toxicity of fluorouracil.
- Leucovorin Calcium + Sulfamethoxazole— ( 7.1 , 7.2 ) Trimethoprim-Sulfamethoxazole : Avoid concomitant use of leucovorin calcium tablets with trimethoprim-sulf…
Moderate (5)
- Leucovorin Calcium + Glucarpidase— Glucarpidase can decrease leucovorin concentrations, reducing the effect of leucovorin rescue. Administer at least 2 hou…
- Leucovorin Calcium + Methotrexate— High doses of leucovorin may reduce the efficacy of intrathecally administered methotrexate.
- Leucovorin Calcium + Phenobarbital— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…
- Leucovorin Calcium + Phenytoin— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…
- Leucovorin Calcium + Primidone— Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible childr…