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Cenobamate

Also known as: Xcopri, Xcopri Maintenance Pack, Xcopri Titration Pack

Sodium Channel AntagonistsGABA A Receptor Positive ModulatorsCytochrome P450 2B6 Inhibitors

Route: Oral

6 interactions on record

Cenobamate has 6 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clobazam, Phenobarbital, Phenytoin. Patients taking Cenobamate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 6
Major: 3
Moderate: 3

Major (3)

Cenobamate + Clobazam— XCOPRI increases desmethylclobazam (active metabolite) plasma concentrations, increasing risk of adverse reactions; dosa…
Cenobamate + Phenobarbital— XCOPRI increases phenobarbital plasma concentrations, increasing risk of adverse reactions; dosage reduction recommended…
Cenobamate + Phenytoin— XCOPRI increases phenytoin plasma concentrations approximately 2-fold, requiring gradual dosage reduction by up to 50% d…

Moderate (3)

Cenobamate + Carbamazepine— XCOPRI decreases carbamazepine plasma concentrations, potentially reducing efficacy; dosage increase recommended.
Cenobamate + Lamotrigine— XCOPRI decreases lamotrigine plasma concentrations, potentially reducing efficacy; dosage increase recommended.
Cenobamate + Oral Contraceptives— XCOPRI decreases oral contraceptive effectiveness; women should use additional or alternative non-hormonal birth control…

Cenobamate + Clobazam⚠️Major

XCOPRI increases desmethylclobazam (active metabolite) plasma concentrations, increasing risk of adverse reactions; dosage reduction recommended.

Cenobamate + Phenobarbital⚠️Major

XCOPRI increases phenobarbital plasma concentrations, increasing risk of adverse reactions; dosage reduction recommended.

Cenobamate + Phenytoin⚠️Major

XCOPRI increases phenytoin plasma concentrations approximately 2-fold, requiring gradual dosage reduction by up to 50% during titration.

Cenobamate + Carbamazepine🟡Moderate

XCOPRI decreases carbamazepine plasma concentrations, potentially reducing efficacy; dosage increase recommended.

Cenobamate + Lamotrigine🟡Moderate

XCOPRI decreases lamotrigine plasma concentrations, potentially reducing efficacy; dosage increase recommended.

Cenobamate + Oral Contraceptives🟡Moderate

XCOPRI decreases oral contraceptive effectiveness; women should use additional or alternative non-hormonal birth control.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.