Does Cenobamate Interact with Clobazam?
Cenobamate and Clobazam have a major drug interaction according to U.S. FDA drug labeling data. XCOPRI increases desmethylclobazam (active metabolite) plasma concentrations, increasing risk of adverse reactions; dosage reduction recommended. The mechanism involves increased plasma concentrations of active metabolite. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Cenobamate Class
- Sodium Channel Antagonists
- Clobazam Class
- Benzodiazepine
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Cenobamate and Clobazam occurs because increased plasma concentrations of active metabolite. Clinically, this means xcopri increases desmethylclobazam (active metabolite) plasma concentrations, increasing risk of adverse reactions; dosage reduction recommended. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Cenobamate and your doctor is considering prescribing Clobazam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider