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Moxifloxacin Hydrochloride

Also known as: Moxifloxacin Hydrochloride

Route: Oral

Check Moxifloxacin Hydrochloride Interactions →

15 interactions on record⛔ Black Box Warning

Moxifloxacin Hydrochloride has 15 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Class Ia Antiarrhythmics, Class Iii Antiarrhythmics, Acidifying Agents. Patients taking Moxifloxacin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 15
Contraindicated: 2
Major: 4
Moderate: 8

Contraindicated (2)

Moxifloxacin Hydrochloride + Class Ia Antiarrhythmics— Proarrhythmic effect may be enhanced. Avoid concomitant use.
Moxifloxacin Hydrochloride + Class Iii Antiarrhythmics— Proarrhythmic effect may be enhanced. Avoid concomitant use.

Major (4)

Moxifloxacin Hydrochloride + Acidifying Agents— Disturbances of blood glucose including hyperglycemia and hypoglycemia reported. Carefully monitor blood glucose during …
Moxifloxacin Hydrochloride + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Concomitant use with NSAIDs may increase risk of CNS stimulation and convulsions.
Moxifloxacin Hydrochloride + Sotalol— Class III antiarrhythmic that may further increase QTc interval when combined with moxifloxacin, with proarrhythmic effe…
Moxifloxacin Hydrochloride + Warfarin— Enhanced anticoagulant effect. Monitor prothrombin time/INR and bleeding closely.

Moderate (8)

Moxifloxacin Hydrochloride + Antacids (Aluminum- Or Magnesium-Containing)— Decreased moxifloxacin absorption due to chelate formation. Take moxifloxacin at least 4 hours before or 8 hours after a…
Moxifloxacin Hydrochloride + Antacids Containing Calcium— Multivalent cations in antacids form chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin …
Moxifloxacin Hydrochloride + Didanosine— Divalent and trivalent cations may substantially interfere with moxifloxacin absorption. Take moxifloxacin at least 4 ho…
Moxifloxacin Hydrochloride + Iron Supplements— Metal cations interfere with moxifloxacin absorption. Take moxifloxacin at least 4 hours before or 8 hours after multivi…
Moxifloxacin Hydrochloride + Moxifloxacin— 7 DRUG INTERACTIONS Interacting Drug Interaction Multivalent cation-containing products including: antacids, sucralfate,…
Moxifloxacin Hydrochloride + Multivitamin— Decreased moxifloxacin absorption, particularly those containing iron or zinc. Take moxifloxacin at least 4 hours before…
Moxifloxacin Hydrochloride + Sucralfate— Decreased moxifloxacin absorption due to chelate formation. Take moxifloxacin at least 4 hours before or 8 hours after s…
Moxifloxacin Hydrochloride + Zinc— Zinc forms chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or…

Moxifloxacin Hydrochloride + Class Ia Antiarrhythmics⛔Contraindicated

Proarrhythmic effect may be enhanced. Avoid concomitant use.

Moxifloxacin Hydrochloride + Class Iii Antiarrhythmics⛔Contraindicated

Proarrhythmic effect may be enhanced. Avoid concomitant use.

Moxifloxacin Hydrochloride + Acidifying Agents⚠️Major

Disturbances of blood glucose including hyperglycemia and hypoglycemia reported. Carefully monitor blood glucose during co-administration.

Moxifloxacin Hydrochloride + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)⚠️Major

Concomitant use with NSAIDs may increase risk of CNS stimulation and convulsions.

Moxifloxacin Hydrochloride + Sotalol⚠️Major

Class III antiarrhythmic that may further increase QTc interval when combined with moxifloxacin, with proarrhythmic effects. Avoid concomitant use.

Moxifloxacin Hydrochloride + Warfarin⚠️Major

Enhanced anticoagulant effect. Monitor prothrombin time/INR and bleeding closely.

Moxifloxacin Hydrochloride + Antacids (Aluminum- Or Magnesium-Containing)🟡Moderate

Decreased moxifloxacin absorption due to chelate formation. Take moxifloxacin at least 4 hours before or 8 hours after antacids.

Moxifloxacin Hydrochloride + Antacids Containing Calcium🟡Moderate

Multivalent cations in antacids form chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 hours after antacids.

Moxifloxacin Hydrochloride + Didanosine🟡Moderate

Divalent and trivalent cations may substantially interfere with moxifloxacin absorption. Take moxifloxacin at least 4 hours before or 8 hours after didanosine.

Moxifloxacin Hydrochloride + Iron Supplements🟡Moderate

Metal cations interfere with moxifloxacin absorption. Take moxifloxacin at least 4 hours before or 8 hours after multivitamins.

Moxifloxacin Hydrochloride + Moxifloxacin🟡Moderate

7 DRUG INTERACTIONS Interacting Drug Interaction Multivalent cation-containing products including: antacids, sucralfate, multivitamins Decreased moxifloxacin hydrochloride absorption. Take moxifloxacin tablet at least 4 hours before or 8 hours after these products. ( 5.3 , 7.5 ) Antidiabetic agents Carefully monitor blood glucose ( 5.10 , 7.3 ) 7.1 Antacids, Sucralfate, Multivitamins and Other Products Containing Multivalent Cations Fluoroquinolones, including moxifloxacin hydrochloride, form chelates with alkaline earth and transition metal cations.

Moxifloxacin Hydrochloride + Multivitamin🟡Moderate

Decreased moxifloxacin absorption, particularly those containing iron or zinc. Take moxifloxacin at least 4 hours before or 8 hours after multivitamins.

Moxifloxacin Hydrochloride + Sucralfate🟡Moderate

Decreased moxifloxacin absorption due to chelate formation. Take moxifloxacin at least 4 hours before or 8 hours after sucralfate.

Moxifloxacin Hydrochloride + Zinc🟡Moderate

Zinc forms chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 hours after zinc products.

Moxifloxacin Hydrochloride + Quinoloneℹ️Unknown

( 5.13 , 7.2 ) 7.1 Warfarin Quinolones, including moxifloxacin, have been reported to enhance the anticoagulant effects of warfarin or its derivatives in the patient population. Therefore, the prothrombin time, International Normalized Ratio (INR), or other suitable anticoagulation tests should be closely monitored if a quinolone is administered concomitantly with warfarin or its derivatives [see Adverse Reactions ( 6 , 6.1 ,), Clinical Pharmacology ( 12.3 ), and Patient Counseling Information ( 17 )]. 7.2 Antidiabetic Agents Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with fluoroquinolones and an antidiabetic agent.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.