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Dihydrocodeine

3 interactions on record

Dihydrocodeine has 3 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alprazolam, Alprazolam C-Iv. Patients taking Dihydrocodeine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Major: 2

Major (2)

Dihydrocodeine + Alprazolam— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.
Dihydrocodeine + Alprazolam C-Iv— Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monito…

Dihydrocodeine + Alprazolam⚠️Major

Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites.

Dihydrocodeine + Alprazolam C-Iv⚠️Major

Concomitant use increases risk of respiratory depression due to additive CNS effects at different receptor sites. Monitor closely for respiratory depression and sedation.

Dihydrocodeine + Acetaminophen, Caffeine, Dihydrocodeine Bitartrateℹ️Unknown

Drug Interactions: Dihydrocodeine with Other Central Nervous System Depressants: Patients receiving other opioid analgesics, sedatives or hypnotics, muscle relaxants, general anesthetics, centrally acting anti-emetics, phenothiazines or other tranquilizers, or alcohol concomitantly with this combination product may exhibit additive depressant effects on the central nervous system. Dihydrocodeine with Monoamine Oxidase Inhibitors: Dihydrocodeine, like all opioid analgesics, interacts with monoamine oxidase inhibitors causing central nervous system excitation and hypertension. Dihydrocodeine with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (i.e., pentazocine, nalbuphine, butorphanol and buprenorphine) may reduce the analgesic effect of this combination product.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.