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Bexarotene

Also known as: Bexarotene

Retinoid

Route: Oral

12 interactions on record⛔ Black Box Warning

Bexarotene has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Deet, Gemfibrozil, Oral Contraceptives. Patients taking Bexarotene should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 1
Major: 2
Moderate: 8

Contraindicated (1)

Bexarotene + Deet— Patients applying bexarotene gel should not concurrently use DEET. Animal toxicology study showed increased DEET toxicit…

Major (2)

Bexarotene + Gemfibrozil— Concomitant administration increases plasma concentrations of bexarotene. Concomitant use is not recommended.
Bexarotene + Oral Contraceptives— Bexarotene may reduce plasma concentrations of oral or systemic hormonal contraceptives. Non-hormonal contraception is s…

Moderate (8)

Bexarotene + Atorvastatin— Bexarotene decreased atorvastatin exposure (AUC) by approximately 50% through CYP3A4 induction.
Bexarotene + Carboplatin— Co-administration with paclitaxel increased bexarotene exposure 2-fold. No effect on carboplatin exposure when given alo…
Bexarotene + Erythromycin— Concomitant erythromycin could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Grapefruit Juice— Concomitant grapefruit juice could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases…
Bexarotene + Itraconazole— Concomitant itraconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Ketoconazole— Concomitant ketoconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Paclitaxel— Bexarotene decreased paclitaxel exposure (AUC) by 19%. When combined with carboplatin, paclitaxel exposure was increased…
Bexarotene + Tamoxifen— Bexarotene decreased tamoxifen plasma concentrations by approximately 35%, possibly through CYP3A4 induction.

Bexarotene + Deet⛔Contraindicated

Patients applying bexarotene gel should not concurrently use DEET. Animal toxicology study showed increased DEET toxicity when included in formulation.

Bexarotene + Gemfibrozil⚠️Major

Concomitant administration increases plasma concentrations of bexarotene. Concomitant use is not recommended.

Bexarotene + Oral Contraceptives⚠️Major

Bexarotene may reduce plasma concentrations of oral or systemic hormonal contraceptives. Non-hormonal contraception is strongly recommended for females with reproductive potential.

Bexarotene + Atorvastatin🟡Moderate

Bexarotene decreased atorvastatin exposure (AUC) by approximately 50% through CYP3A4 induction.

Bexarotene + Carboplatin🟡Moderate

Co-administration with paclitaxel increased bexarotene exposure 2-fold. No effect on carboplatin exposure when given alone.

Bexarotene + Erythromycin🟡Moderate

Concomitant erythromycin could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Grapefruit Juice🟡Moderate

Concomitant grapefruit juice could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Itraconazole🟡Moderate

Concomitant itraconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Ketoconazole🟡Moderate

Concomitant ketoconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Paclitaxel🟡Moderate

Bexarotene decreased paclitaxel exposure (AUC) by 19%. When combined with carboplatin, paclitaxel exposure was increased 2-fold.

Bexarotene + Tamoxifen🟡Moderate

Bexarotene decreased tamoxifen plasma concentrations by approximately 35%, possibly through CYP3A4 induction.

Bexarotene + Tolbutamideℹ️Unknown

DRUG-DRUG INTERACTIONS Patients who are applying bexarotene gel should not concurrently use products that contain DEET ( N,N -diethyl- m -toluamide), a common component of insect repellent products.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.