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Bexarotene

Also known as: Targretin

Retinoid

Route: Oral

12 interactions on record⛔ Black Box Warning

Bexarotene has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Deet, Gemfibrozil, Oral Contraceptives. Patients taking Bexarotene should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 12
Contraindicated: 1
Major: 2
Moderate: 8

Contraindicated (1)

Bexarotene + Deet— Patients applying bexarotene gel should not concurrently use DEET. Animal toxicology study showed increased DEET toxicit…

Major (2)

Bexarotene + Gemfibrozil— Concomitant administration increases plasma concentrations of bexarotene. Concomitant use is not recommended.
Bexarotene + Oral Contraceptives— Bexarotene may reduce plasma concentrations of oral or systemic hormonal contraceptives. Non-hormonal contraception is s…

Moderate (8)

Bexarotene + Atorvastatin— Bexarotene decreased atorvastatin exposure (AUC) by approximately 50% through CYP3A4 induction.
Bexarotene + Carboplatin— Co-administration with paclitaxel increased bexarotene exposure 2-fold. No effect on carboplatin exposure when given alo…
Bexarotene + Erythromycin— Concomitant erythromycin could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Grapefruit Juice— Concomitant grapefruit juice could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases…
Bexarotene + Itraconazole— Concomitant itraconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Ketoconazole— Concomitant ketoconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unl…
Bexarotene + Paclitaxel— Bexarotene decreased paclitaxel exposure (AUC) by 19%. When combined with carboplatin, paclitaxel exposure was increased…
Bexarotene + Tamoxifen— Bexarotene decreased tamoxifen plasma concentrations by approximately 35%, possibly through CYP3A4 induction.

Bexarotene + Deet⛔Contraindicated

Patients applying bexarotene gel should not concurrently use DEET. Animal toxicology study showed increased DEET toxicity when included in formulation.

Bexarotene + Gemfibrozil⚠️Major

Concomitant administration increases plasma concentrations of bexarotene. Concomitant use is not recommended.

Bexarotene + Oral Contraceptives⚠️Major

Bexarotene may reduce plasma concentrations of oral or systemic hormonal contraceptives. Non-hormonal contraception is strongly recommended for females with reproductive potential.

Bexarotene + Atorvastatin🟡Moderate

Bexarotene decreased atorvastatin exposure (AUC) by approximately 50% through CYP3A4 induction.

Bexarotene + Carboplatin🟡Moderate

Co-administration with paclitaxel increased bexarotene exposure 2-fold. No effect on carboplatin exposure when given alone.

Bexarotene + Erythromycin🟡Moderate

Concomitant erythromycin could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Grapefruit Juice🟡Moderate

Concomitant grapefruit juice could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Itraconazole🟡Moderate

Concomitant itraconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Ketoconazole🟡Moderate

Concomitant ketoconazole could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations.

Bexarotene + Paclitaxel🟡Moderate

Bexarotene decreased paclitaxel exposure (AUC) by 19%. When combined with carboplatin, paclitaxel exposure was increased 2-fold.

Bexarotene + Tamoxifen🟡Moderate

Bexarotene decreased tamoxifen plasma concentrations by approximately 35%, possibly through CYP3A4 induction.

Bexarotene + Tolbutamideℹ️Unknown

DRUG-DRUG INTERACTIONS Patients who are applying bexarotene gel should not concurrently use products that contain DEET ( N,N -diethyl- m -toluamide), a common component of insect repellent products.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.