Chloramphenicol has 24 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ceftazidime, Glyburide And Metformin Hydrochloride, Tacrolimus. Patients taking Chloramphenicol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Contraindicated
- 1
- Major
- 2
- Moderate
- 20
Contraindicated (1)
- Chloramphenicol + Ceftazidime— Shown to be antagonistic to ceftazidime based on in vitro studies. Combination should be avoided, particularly when bact…
Major (2)
- Chloramphenicol + Glyburide And Metformin Hydrochloride— Chloramphenicol may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.
- Chloramphenicol + Tacrolimus— May increase tacrolimus whole blood trough concentrations and increase risk of serious adverse reactions including neuro…
Moderate (20)
- Chloramphenicol + Amoxicillin— Chloramphenicol may interfere with bactericidal effects of amoxicillin, though clinical significance is not well documen…
- Chloramphenicol + Ampicillin— May interfere with the bactericidal effect of ampicillin.
- Chloramphenicol + Bromocriptine Mesylate— Bromocriptine may increase the unbound fraction of highly protein-bound chloramphenicol, potentially altering its effect…
- Chloramphenicol + Cyanocobalamin— Chloramphenicol may decrease the efficacy of Cyanocobalamin Nasal Spray when used for treatment of anemia. Monitor for r…
- Chloramphenicol + Entacapone— Chloramphenicol may interfere with biliary excretion, glucuronidation, and intestinal beta-glucuronidase of entacapone; …
- Chloramphenicol + Fosphenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Chloramphenicol + Glibenclamide— May potentiate hypoglycemic action of glyburide; patient should be closely observed for hypoglycemia.
- Chloramphenicol + Glimepiride— Highly protein-bound drug that may increase glucose-lowering effect of glimepiride, increasing susceptibility to hypogly…
- Chloramphenicol + Glipizide— Chloramphenicol may potentiate hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia whe…
- Chloramphenicol + Glipizide And Metformin Hydrochloride— Chloramphenicol may potentiate the hypoglycemic action of glipizide. Patient should be observed closely for hypoglycemia…
- Chloramphenicol + Glyburide-Metformin Hydrochloride— May potentiate hypoglycemic action of glyburide; monitor for hypoglycemia.
- Chloramphenicol + Methotrexate— Oral antibiotics like chloramphenicol may decrease intestinal absorption of methotrexate or interfere with enterohepatic…
- Chloramphenicol + Multiple Vitamins Injection— In patients with pernicious anemia, chloramphenicol may inhibit hematologic response to vitamin B12 therapy.
- Chloramphenicol + Penicillin G— Bacteriostatic antibacterial may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Chloramphenicol + Penicillin G Benzathine— Chloramphenicol may antagonize the bactericidal effect of penicillin G benzathine by interfering with active bacterial g…
- Chloramphenicol + Penicillin G Potassium— Bacteriostatic antibiotic may antagonize the bactericidal effect of penicillin. Concurrent use should be avoided.
- Chloramphenicol + Penicillin G Sodium— May antagonize the bactericidal effect of penicillin. Concurrent use should be avoided, though clinical significance is …
- Chloramphenicol + Phenytoin— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Chloramphenicol + Phenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Chloramphenicol + Rifapentine— Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary.