Hydrocortisone Sodium Succinate has 18 known drug interactions based on U.S. FDA drug labeling data. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aminoglutethimide, Amphotericin B, Anticholinesterase Agents. Patients taking Hydrocortisone Sodium Succinate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 8
- Moderate
- 10
Major (8)
- Hydrocortisone Sodium Succinate + Aminoglutethimide— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Hydrocortisone Sodium Succinate + Amphotericin B— Concomitant use with amphotericin B and hydrocortisone has been followed by cardiac enlargement and congestive heart fai…
- Hydrocortisone Sodium Succinate + Anticholinesterase Agents— Concomitant use may produce severe weakness in patients with myasthenia gravis. Anticholinesterase agents should be with…
- Hydrocortisone Sodium Succinate + Cyclosporine— Increased activity of both cyclosporine and corticosteroids may occur concurrently. Convulsions have been reported with …
- Hydrocortisone Sodium Succinate + Digitalis Glycosides— Patients on digitalis glycosides may be at increased risk of arrhythmias due to corticosteroid-induced hypokalemia.
- Hydrocortisone Sodium Succinate + Erythromycin— Macrolide antibiotic causing significant decrease in corticosteroid clearance, potentially increasing corticosteroid lev…
- Hydrocortisone Sodium Succinate + Ketoconazole— Ketoconazole significantly decreases metabolism of certain corticosteroids by up to 60%, leading to increased risk of co…
- Hydrocortisone Sodium Succinate + Troleandomycin— Macrolide antibiotic causing significant decrease in corticosteroid clearance, potentially increasing corticosteroid lev…
Moderate (10)
- Hydrocortisone Sodium Succinate + Acetylsalicylic Acid— Concomitant use of aspirin and corticosteroids increases risk of gastrointestinal side effects. Aspirin should be used c…
- Hydrocortisone Sodium Succinate + Barbiturates— Barbiturates induce cytochrome P450 3A4 enzyme activity, enhancing corticosteroid metabolism and requiring increased cor…
- Hydrocortisone Sodium Succinate + Carbamazepine— Carbamazepine induces cytochrome P450 3A4 enzyme activity, enhancing corticosteroid metabolism and requiring increased c…
- Hydrocortisone Sodium Succinate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids, reducing corticosteroid effects.
- Hydrocortisone Sodium Succinate + Estrogens— Estrogens may decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.
- Hydrocortisone Sodium Succinate + Isoniazid— Serum concentrations of isoniazid may be decreased when used with corticosteroids.
- Hydrocortisone Sodium Succinate + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.
- Hydrocortisone Sodium Succinate + Phenytoin— Phenytoin induces cytochrome P450 3A4 enzyme activity, enhancing corticosteroid metabolism and requiring increased corti…
- Hydrocortisone Sodium Succinate + Rifampin— Rifampin induces cytochrome P450 3A4 enzyme activity, enhancing corticosteroid metabolism and requiring increased cortic…
- Hydrocortisone Sodium Succinate + Warfarin— Coadministration usually results in inhibition of response to warfarin. Coagulation indices should be monitored frequent…