Chlordiazepoxide has 14 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Butalbital, Acetaminophen And Caffeine, Butalbital, Aspirin, And Caffeine, Acetaminophen And Codeine Phosphate. Patients taking Chlordiazepoxide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Major
- 2
- Moderate
- 10
- Minor
- 2
Major (2)
- Chlordiazepoxide + Butalbital, Acetaminophen And Caffeine— Chlordiazepoxide (tranquilizer) may enhance effects causing increased CNS depression.
- Chlordiazepoxide + Butalbital, Aspirin, And Caffeine— Butalbital causes increased CNS depression when combined with tranquilizers such as chlordiazepoxide.
Moderate (10)
- Chlordiazepoxide + Acetaminophen And Codeine Phosphate— May enhance CNS depressant effects, causing increased CNS depression.
- Chlordiazepoxide + Butalbital And Acetaminophen— Chlordiazepoxide may enhance the effects of butalbital and acetaminophen, causing increased CNS depression.
- Chlordiazepoxide + Butalbital And Acetaminophen Tablets— Chlordiazepoxide may have enhanced effects when combined with butalbital and acetaminophen, causing increased CNS depres…
- Chlordiazepoxide + Butalbital, Acetaminophen, And Caffeine Capsules— Chlordiazepoxide may enhance CNS depressant effects of the combination.
- Chlordiazepoxide + Cimetidine— Cimetidine reduces hepatic metabolism of chlordiazepoxide, delaying elimination and increasing blood levels. Dosage adju…
- Chlordiazepoxide + Cimetidine Hydrochloride— Cimetidine reduces hepatic metabolism of chlordiazepoxide, delaying elimination and increasing blood levels.
- Chlordiazepoxide + Desipramine Hydrochloride— Benzodiazepine with additive sedative effects when combined with desipramine; careful consideration of pharmacology requ…
- Chlordiazepoxide + Fosphenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Chlordiazepoxide + Phenytoin— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Chlordiazepoxide + Phenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
Minor (2)
- Chlordiazepoxide + Prazosin— Prazosin has been administered without adverse drug interaction with chlordiazepoxide in limited clinical experience.
- Chlordiazepoxide + Prazosin Hydrochloride— Administered without adverse drug interaction in limited clinical experience.