Alpha-Blockers has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Hyaluronidase, Hyaluronidase, Ovine, Silodosin. Patients taking Alpha-Blockers should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 3
- Major
- 5
- Moderate
- 4
Contraindicated (3)
- Alpha-Blockers + Hyaluronidase— Hyaluronidase should not be used to enhance the dispersion and absorption of alpha agonist drugs.
- Alpha-Blockers + Hyaluronidase, Ovine— Hyaluronidase should not be used to enhance absorption and dispersion of alpha agonist drugs.
- Alpha-Blockers + Silodosin— Pharmacodynamic interactions may be expected. Silodosin should not be used in combination with other alpha-blockers.
Major (5)
- Alpha-Blockers + Avanafil— Concomitant use can cause significant additive blood pressure reduction leading to symptomatic hypotension (dizziness, l…
- Alpha-Blockers + Sildenafil— Use caution with alpha-blockers due to potential additive blood pressure-lowering effects. Initiate sildenafil at lowest…
- Alpha-Blockers + Sildenafil Citrate— Potential additive blood pressure-lowering effects. Initiate sildenafil at lowest dose after patients are stable on alph…
- Alpha-Blockers + Tadalafil— Caution advised when tadalafil is coadministered with alpha-blockers. Both are vasodilators with blood-pressure-lowering…
- Alpha-Blockers + Vardenafil— Concomitant use may cause additive blood pressure lowering effects. Patients should not initiate vardenafil with alpha-b…
Moderate (4)
- Alpha-Blockers + Alfuzosin Hydrochloride— Should not be used in combination with alfuzosin. Pharmacokinetic and pharmacodynamic interactions may be expected.
- Alpha-Blockers + Dopamine Hydrochloride— Antagonize peripheral vasoconstriction caused by high-dose dopamine but do not antagonize renal and mesenteric vasodilat…
- Alpha-Blockers + Oxymetazoline Hydrochloride Ophthalmic— Caution advised in patients receiving alpha adrenergic receptor antagonists for cardiovascular disease or benign prostat…
- Alpha-Blockers + Phenylephrine Hydrochloride— Alpha-adrenergic antagonists decrease phenylephrine blood pressure effect through antagonistic interaction.