Amphotericin B Liposome has 11 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Leukocyte Transfusions, Acidifying Agents, Corticosteroids. Patients taking Amphotericin B Liposome should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 1
- Moderate
- 10
Major (1)
- Amphotericin B Liposome + Leukocyte Transfusions— Acute pulmonary toxicity has been reported in patients simultaneously receiving intravenous amphotericin B and leukocyte…
Moderate (10)
- Amphotericin B Liposome + Acidifying Agents— Concurrent use may enhance potential for renal toxicity, bronchospasm, and hypotension. Should be given concomitantly wi…
- Amphotericin B Liposome + Corticosteroids— Concurrent use may potentiate hypokalemia, which could predispose patient to cardiac dysfunction. Serum electrolytes and…
- Amphotericin B Liposome + Cotrimoxazole— In vitro and in vivo animal studies suggest imidazoles may induce fungal resistance to amphotericin B. Combination thera…
- Amphotericin B Liposome + Digitalis Glycosides— Concurrent use may induce hypokalemia and potentiate digitalis toxicity. Serum potassium levels should be closely monito…
- Amphotericin B Liposome + Fluconazole— In vitro and in vivo animal studies suggest imidazoles may induce fungal resistance to amphotericin B. Combination thera…
- Amphotericin B Liposome + Flucytosine— Concurrent use may increase flucytosine toxicity by possibly increasing cellular uptake and/or impairing renal excretion…
- Amphotericin B Liposome + Ketoconazole— In vitro and in vivo animal studies suggest imidazoles may induce fungal resistance to amphotericin B. Combination thera…
- Amphotericin B Liposome + Miconazole— In vitro and in vivo animal studies suggest imidazoles may induce fungal resistance to amphotericin B. Combination thera…
- Amphotericin B Liposome + Repository Corticotropin— Concurrent use may potentiate hypokalemia, which could predispose patient to cardiac dysfunction. Serum electrolytes and…
- Amphotericin B Liposome + Tubocurarine— Amphotericin B-induced hypokalemia may enhance curariform effect of skeletal muscle relaxants. Serum potassium levels sh…