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Anagrelide Hydrochloride

Also known as: Agrylin

Route: Oral

Check Anagrelide Hydrochloride Interactions →

17 interactions on record

Anagrelide Hydrochloride has 17 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetylsalicylic Acid, Amiodarone, Chloroquine. Patients taking Anagrelide Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 17
Major: 12
Moderate: 5

Major (12)

Anagrelide Hydrochloride + Acetylsalicylic Acid— Increased risk of bleeding and major hemorrhagic events; greater anti-platelet aggregation when combined.
Anagrelide Hydrochloride + Amiodarone— Avoid concomitant use due to QT prolongation risk.
Anagrelide Hydrochloride + Chloroquine— Avoid concomitant use due to QT prolongation risk.
Anagrelide Hydrochloride + Cilostazol— Avoid use due to exacerbation of inotropic effects as PDE3 inhibitor.
Anagrelide Hydrochloride + Clarithromycin— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (incl…
Anagrelide Hydrochloride + Disopyramide— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (incl…
Anagrelide Hydrochloride + Haloperidol— Avoid concomitant use due to QT prolongation risk.
Anagrelide Hydrochloride + Methadone— Avoid concomitant use due to QT prolongation risk.
Anagrelide Hydrochloride + Milrinone— Avoid use due to exacerbation of inotropic effects as PDE3 inhibitor.
Anagrelide Hydrochloride + Moxifloxacin— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (incl…
Anagrelide Hydrochloride + Pimozide— Avoid concomitant use due to QT prolongation risk.
Anagrelide Hydrochloride + Procainamide— ( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (incl…

Moderate (5)

Anagrelide Hydrochloride + Ciprofloxacin— CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and adjust dose.
Anagrelide Hydrochloride + Fluvoxamine— CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and adjust dose.
Anagrelide Hydrochloride + Omeprazole— CYP1A2 inducer may decrease anagrelide exposure; dose titration may be necessary.
Anagrelide Hydrochloride + Ondansetron— Limited CYP1A2 inhibitory activity may alter ondansetron exposure; monitor accordingly.
Anagrelide Hydrochloride + Theophylline— Limited CYP1A2 inhibitory activity may alter theophylline exposure; monitor accordingly.

Anagrelide Hydrochloride + Acetylsalicylic Acid⚠️Major

Increased risk of bleeding and major hemorrhagic events; greater anti-platelet aggregation when combined.

Anagrelide Hydrochloride + Amiodarone⚠️Major

Avoid concomitant use due to QT prolongation risk.

Anagrelide Hydrochloride + Chloroquine⚠️Major

Avoid concomitant use due to QT prolongation risk.

Anagrelide Hydrochloride + Cilostazol⚠️Major

Avoid use due to exacerbation of inotropic effects as PDE3 inhibitor.

Anagrelide Hydrochloride + Clarithromycin⚠️Major

( 7.3 ) 7.1 Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (including, but not limited to, chloroquine, clarithromycin, haloperidol, methadone, moxifloxacin, amiodarone, disopyramide, procainamide, and pimozide) [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2) ] .

Anagrelide Hydrochloride + Disopyramide⚠️Major

Anagrelide Hydrochloride + Haloperidol⚠️Major

Avoid concomitant use due to QT prolongation risk.

Anagrelide Hydrochloride + Methadone⚠️Major

Avoid concomitant use due to QT prolongation risk.

Anagrelide Hydrochloride + Milrinone⚠️Major

Avoid use due to exacerbation of inotropic effects as PDE3 inhibitor.

Anagrelide Hydrochloride + Moxifloxacin⚠️Major

Anagrelide Hydrochloride + Pimozide⚠️Major

Avoid concomitant use due to QT prolongation risk.

Anagrelide Hydrochloride + Procainamide⚠️Major

Anagrelide Hydrochloride + Ciprofloxacin🟡Moderate

CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and adjust dose.

Anagrelide Hydrochloride + Fluvoxamine🟡Moderate

CYP1A2 inhibitor may increase anagrelide exposure; monitor for cardiovascular events and adjust dose.

Anagrelide Hydrochloride + Omeprazole🟡Moderate

CYP1A2 inducer may decrease anagrelide exposure; dose titration may be necessary.

Anagrelide Hydrochloride + Ondansetron🟡Moderate

Limited CYP1A2 inhibitory activity may alter ondansetron exposure; monitor accordingly.

Anagrelide Hydrochloride + Theophylline🟡Moderate

Limited CYP1A2 inhibitory activity may alter theophylline exposure; monitor accordingly.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.