Memantine Hydrochloride has 5 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Amantadine, Dextromethorphan, Ketamine. Patients taking Memantine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Moderate
- 5
Moderate (5)
- Memantine Hydrochloride + Amantadine— Combined use with memantine has not been systematically evaluated. Both are NMDA antagonists and such use should be appr…
- Memantine Hydrochloride + Dextromethorphan— Combined use with memantine has not been systematically evaluated. Both are NMDA antagonists and such use should be appr…
- Memantine Hydrochloride + Ketamine— Combined use with memantine has not been systematically evaluated. Both are NMDA antagonists and such use should be appr…
- Memantine Hydrochloride + Mao Inhibitors— Carbonic anhydrase inhibitors alter urine pH towards alkaline conditions, which may reduce memantine clearance by about …
- Memantine Hydrochloride + Sodium Bicarbonate— Sodium bicarbonate alters urine pH towards alkaline conditions, which may reduce memantine clearance by about 80% and le…