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Lurbinectedin

Also known as: Zepzelca

Alkylating DrugAlkylating Activity

Route: Intravenous

2 interactions on record

Lurbinectedin has 2 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Grapefruit Products, Seville Oranges. Patients taking Lurbinectedin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 2
Moderate: 2

Moderate (2)

Lurbinectedin + Grapefruit Products— Grapefruit contains strong or moderate CYP3A inhibitors that increase lurbinectedin systemic exposure, which may increas…
Lurbinectedin + Seville Oranges— Seville oranges contain strong or moderate CYP3A inhibitors that increase lurbinectedin systemic exposure, which may inc…

Lurbinectedin + Grapefruit Products🟡Moderate

Grapefruit contains strong or moderate CYP3A inhibitors that increase lurbinectedin systemic exposure, which may increase incidence and severity of adverse reactions.

Lurbinectedin + Seville Oranges🟡Moderate

Seville oranges contain strong or moderate CYP3A inhibitors that increase lurbinectedin systemic exposure, which may increase incidence and severity of adverse reactions.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.