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Oliceridine

Also known as: Olinvyk

Route: Intravenous

8 interactions on record⛔ Black Box Warning

Oliceridine has 8 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Bupropion, Erythromycin, Fluoxetine. Patients taking Oliceridine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Moderate: 7

Moderate (7)

Oliceridine + Bupropion— CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. Ma…
Oliceridine + Erythromycin— CYP3A4 inhibitor (macrolide antibiotic) that increases oliceridine plasma concentration and prolonged opioid adverse rea…
Oliceridine + Fluoxetine— CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. Ma…
Oliceridine + Ketoconazole— CYP3A4 inhibitor (azole-antifungal) that increases oliceridine plasma concentration and prolonged opioid adverse reactio…
Oliceridine + Paroxetine— CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. Ma…
Oliceridine + Quinidine— CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. Ma…
Oliceridine + Ritonavir— CYP3A4 inhibitor (protease inhibitor) that increases oliceridine plasma concentration and prolonged opioid adverse react…

Oliceridine + Bupropion🟡Moderate

CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. May require less frequent dosing and close monitoring for respiratory depression.

Oliceridine + Erythromycin🟡Moderate

CYP3A4 inhibitor (macrolide antibiotic) that increases oliceridine plasma concentration and prolonged opioid adverse reactions. Caution advised with possible less frequent dosing needed.

Oliceridine + Fluoxetine🟡Moderate

CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. May require less frequent dosing and close monitoring for respiratory depression.

Oliceridine + Ketoconazole🟡Moderate

CYP3A4 inhibitor (azole-antifungal) that increases oliceridine plasma concentration and prolonged opioid adverse reactions. Caution advised with possible less frequent dosing needed.

Oliceridine + Paroxetine🟡Moderate

CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. May require less frequent dosing and close monitoring for respiratory depression.

Oliceridine + Quinidine🟡Moderate

CYP2D6 inhibitor that increases oliceridine plasma concentration, resulting in increased or prolonged opioid effects. May require less frequent dosing and close monitoring for respiratory depression.

Oliceridine + Ritonavir🟡Moderate

CYP3A4 inhibitor (protease inhibitor) that increases oliceridine plasma concentration and prolonged opioid adverse reactions. Caution advised with possible less frequent dosing needed.

Oliceridine + Itraconazoleℹ️Unknown

Examples: Inhibitors of CYP3A4: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g., ketoconazole, itraconazole), anti-retroviral agents, selective serotonin re-uptake inhibitors (SSRIs), protease inhibitors (e.g., ritonavir), NS3/4A inhibitors.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.