Chlorpheniramine has 9 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Epinephrine 0.15 Pediatrics, Epinephrine 0.3 Adults. Patients taking Chlorpheniramine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Major
- 4
- Moderate
- 3
- Minor
- 2
Major (4)
- Chlorpheniramine + Epinephrine— Chlorpheniramine potentiates the effects of epinephrine.
- Chlorpheniramine + Epinephrine 0.15 Pediatrics— Effects of epinephrine may be potentiated by the antihistamine chlorpheniramine.
- Chlorpheniramine + Epinephrine 0.3 Adults— Effects of epinephrine may be potentiated by chlorpheniramine.
- Chlorpheniramine + Isoproterenol Hydrochloride— Antihistamine that may potentiate clinical response of isoproterenol.
Moderate (3)
- Chlorpheniramine + Albuterol Sulfate— Chlorpheniramine potentiates the effects of epinephrine.
- Chlorpheniramine + Auvi-Q— Antihistamine that may potentiate the effects of epinephrine.
- Chlorpheniramine + Histamine Phosphate— Antihistamine that suppresses response to histamine. Duration of suppression may be as little as 24 hours.
Minor (2)
- Chlorpheniramine + Terazosin— Terazosin has been used concomitantly with chlorpheniramine in at least 50 patients with no interactions observed.
- Chlorpheniramine + Terazosin Hydrochloride— Used concomitantly with terazosin in at least 50 patients with no interactions observed.